Study_ID string | Objectives string | Included string | Excluded string |
|---|---|---|---|
CRD42023488855 | Are video games an efficacious intervention for cognitive impairment associated with schizophrenia (CIAS) and how do they compare with cognitive remediation? | Cognitive impairment associated with schizophrenia (CIAS). | null |
CRD42025648992 | Primary Question:
What is the effectiveness of deprescribing protocols in reducing adverse drug reactions among older adults with polypharmacy?
Secondary Questions:
How do different deprescribing strategies (e.g., pharmacist-led, physician-guided, technology-assisted) compare in their effectiveness?
What impact do depr... | Polypharmacy is a significant concern in geriatric healthcare, defined as the concurrent use of multiple medications, often leading to adverse drug reactions (ADRs), increased risk of falls, cognitive decline, hospitalizations, and overall diminished quality of life. The complexity of managing multiple medications in o... | null |
CRD420251003850 | This thesis aims to clarify the holistic impact of structured exercise programs (intradialytic, home-based, or hybrid) in adults with chronic kidney disease (CKD), whether dialyzed or non-dialyzed. By comparing these interventions to standard care, we evaluate their efficacy across three key domains: | Adults (≥18 years) with chronic kidney disease (CKD) stages 3–5 per KDIGO classification. Patients on dialysis (hemodialysis [HD] or peritoneal dialysis [PD]) or non-dialyzed. Interventions Structured Exercise Programs: Intradialytic (during HD), home-based, or combined. Study Design Study Types: Randomized cont... | Population Severe Comorbidities: Contraindications to exercise (e.g., unstable angina, decompensated heart failure, recent fractures, or uncontrolled hypertension). Severe cognitive impairment (inability to provide informed consent or follow exercise protocols). Terminal illnesses or life expectancy < 6 months. P... |
CRD42024497822 | Does 5-Nitroimidazole derivatives reduce the parasitic load in animal models of parasitic neglected tropical diseases? | Neglected Tropical Diseases; Chagas Diseases; Leishmaniasis; Malaria All animal models with experimental parasitic neglected tropical diseases. 5-nitroimidazole derivatives treatment. All timings, frequencies and dosages of treatment are eligible for inclusion. We will include randomised controlled trials of pharmaceut... | Animals with co-morbilities; ex vivo, in vitro and in silico models. Treatments with non-5 nitroimidazole derivatives. Studies without a separate control group. |
CRD42020203927 | How does yoga as a therapeutic means affect prehypertension and hypertension in adults compared to usual care or other interventions? | Hypertension. Prehypertension. Yoga in adults. | null |
CRD42024503722 | The aim of this network meta-analysis is to evaluate the intervention effects of three kinds of Traditional Chinese Fitness Exercises in Patients with Parkinson’s disease. | Condition or domain being studied: Parkinson's disease is the second most common neurodegenerative disease, which tends to occur in middle-aged and elderly people, with an incidence of more than 1% over the age of 60. The clinical symptoms of Parkinson's disease include motor symptoms and non-motor symptoms. Among them... | null |
CRD42024572804 | What is the efficacy of Transcranial Magnetic Stimulation (TMS) as a therapeutic Intervention for post- traumatic stress disorder (PTSD) in Adults? | Post-traumatic stress disorder (PTSD), previously known as battle fatigue syndrome or shell shock , is a severe mental disturbance condition that is normally triggered by the experience of some frightening/scary events or trauma where a person undergoes some serious physical or mental harm or threatened. PTSD is a long... | null |
CRD42024541967 | Which non-pharmacological interventions are effective in preventing or managing paediatric delirium in critical care? | Delirium is relatively common in paediatric intensive care, reportedly affecting at least 1 in 3 children. However, detecting paediatric delirium (PD) can be complex. Understanding facets of presentation, risk factors, screening, and the ability to differentiate it from behaviours complicated by critical illness burden... | null |
CRD420250650645 | This meta-analysis evaluated the efficacy of negative symptoms and treatment acceptability as primary outcomes while assessing the severity of positive symptoms and overall psychiatric symptoms as secondary outcomes. | Schizophrenia; Intermittent theta burst stimulation Schizophrenia (SCZ) is a chronic, severe, and debilitating mental disorder, with a lifetime prevalence rate of approximately 0.7% in China. Negative symptoms are a core feature of schizophrenia, affecting 40-60% of patients.Compared to positive symptoms, patients with... | null |
CRD420250655343 | Does the use of probiotics and synbiotics reduce gastrointestinal symptoms and improve the quality of life in patients with IBS-C? | Irritable Bowel Syndrome with Constipation (IBS-C) is a gastrointestinal disorder characterized by chronic abdominal pain or discomfort associated with altered bowel habits, specifically constipation. Patients with this condition often experience infrequent, hard, or lumpy stools, straining during defecation, and a sen... | null |
CRD42024588059 | What is the efficacy and safety of Janus kinase (JAK) inhibitors in the treatment of IgG4-related disease (IgG4-RD) across diverse organ involvement and disease presentations? | IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder characterized by lymphoplasmacytic infiltration of IgG4-positive plasma cells and storiform fibrosis in multiple organs. Current treatment primarily involves glucocorticoids and immunosuppressive agents; however, long-term use of these therapies ca... | null |
CRD420250598206 | The purpose of this study was to assess Yuejuwan (YJW) as a Chinese medicine formula for animal models of depression in rodents.Population (P): Animal models of depression in rodentsanimal Intervention (I): Yuejuwan Comparison (C): Randomized controlled experimentOutcomes (O): Behavioral changes | Depression. All animals regardless of species, strains, age and sex. Yuejuwan (YJW), or YJW plus western medicine. | Non-animal studies or with co-morbidities. No Yuejuwan (YJW) treatment , No YJW plus western medicine treatment. Control animals went under effective (no-sham) surgery. |
CRD420251001904 | Is the effect and safety of Fu's Subcutaneous Needling better than that of acupuncture for patients with lumbar intervertebral disc protrusion? | Patients with Lumbar Disc Herniation. There is no restriction on age, gender, race, etc. No NO Randomized controlled trial of Fu's Subcutaneous Needling for lumbar disc herniation. Publication time is not restricted by country. Language is limited to Chinese and English. | Not patients with Lumbar Disc Herniation. The experimental group did not use Fu's Subcutaneous Needling, or the Fu's Subcutaneous Needling were not used in the control group. The control group cannot use Fu's Subcutaneous Needling, or combine two or more intervention measures. Other languages. Publishing duplicate stud... |
CRD42024595642 | "What is the potential effect of the compound 2-AEH2F on controlling cancer progression?"
PICO
(P) target population comprises individuals diagnosed with cancer.
(I) intervention refers to the administration of the compound 2-AEH2F.
(C) comparative, people undergoing conventional treatment will be considered.
(O) Expec... | Cancer is a complex and multifactorial disease characterized by abnormal cell growth and spread. This process is governed by a series of genetic and epigenetic alterations that lead to dysfunction of the normal mechanisms controlling cell growth and death. The pathophysiology of cancer involves a series of events that ... | null |
CRD420250655838 | 1. How effective is footwear as a management strategy for people with inflammatory arthritis (IA)? 2. How effective is footwear as a management strategy for people with connective tissue disorders (CTDs)? | The conditions that are being studied in this systematic review will be inflammatory arthritis and connective tissue disorders. Inflammatory arthritis encompasses many forms of arthritis including, rheumatoid arthritis, spondyloarthropathies and osteoarthritis which are all chronic inflammatory joint diseases. An indiv... | null |
CRD42018093507 | What are the effects of computerized clinical decision support systems (CDSS) for the prescribing of oral anticoagulant therapy, compared to routine care? Which CDSS characteristics or implementation features are associated with success vs. failure? | Prescription of oral anticoagulants | null |
CRD420250639065 | "What is the efficacy and safety of bioactive molecules derived from amphibian venoms in the treatment of cancer, compared to conventional treatments or no treatment, in in vitro and in vivo models?" | It's being modelled a revision about burn peptides of the dermaseptin class and their therapeutic use in cancer treatment In vivo murine and lagomorph models of treatment of any type of cancer presented in the studies found*Rats (Wistar; Balc; Sprague-Dawley);within our search strategy, previous screenings will be cons... | Any other type of animal; not using a cancer treatment model Any other type of intervention that has not contributed to treating cancer in animals and cells. It was not compared with treatments that used non-dermaseptin and chemotherapeutic-based models. |
CRD420250619643 | What are the efficacy and safety of the different androgen receptor signaling inhibitors (ARSIs) in metastatic hormone-sensitive prostate cancer (mHSPC), including subgroup analyses for patients with high tumor volume? | Prostate Cancer; Hormone Therapy; Efficacy; Safety The disease domain being studied in this systematic review and meta-analysis is the treatment of metastatic hormone-sensitive prostate cancer(mHSPC), defined as advanced prostate cancer that has not received hormone therapy. Prostate cancer was the most commonly diagno... | The article would be excluded if it met the following criteria:(1) duplicative; (2) the irrelevant to mHSPC; (3) the publishment was not in English; (4) the data was not extractable in the article. (5)animal experiments. |
CRD42024564954 | What is the impact of palliative care delivered through overnight U.S. summer camps (intervention), compared to either no specific intervention or standard palliative practice, on quality of life (outcome) of caregivers of young people aged 7 up to 18 with serious or chronic illness (population)?" | Children and adolescents face a variety of serious and chronic illnesses and conditions. Parents/caregivers of children with serious and chronic illnesses face significant risks including high rates of self-harm, depression, and anxiety. Evidence suggests that Out of School Time (OST), like summer camps, can serve as a... | null |
CRD42024616858 | Population
Inclusion:
Patients diagnosed with intracranial hypertension due to:
Traumatic brain injury (TBI)
Spontaneous intracerebral hemorrhage (ICH)
Exclusion:
Patients with pre-existing conditions impacting intracranial pressure (e.g., hydrocephalus unrelated to TBI/ICH, brain tumors)
Patients with contraindication... | This review focuses on intracranial hypertension, a critical condition characterized by elevated intracranial pressure (ICP) that can result from traumatic brain injury (TBI) or spontaneous intracerebral hemorrhage (ICH). Effective management of elevated ICP is vital to prevent secondary brain injury, improve neurologi... | null |
CRD420250643041 | 1. What tinnitus-related clinical practice guidelines have been published in the last 10 years?2. What are the key recommendations provided by these guidelines regarding the diagnosis and treatment of subjective tinnitus?3. How were these guidelines developed, including their methodological rigor, evidence bases, and s... | Subjective tinnitus impacts a substantial global population, reducing quality of life for millions, yet current clinical guidelines exhibit inconsistent quality and methodological rigor, contributing to heterogeneous practices and suboptimal outcomes. Key challenges persist in its management: etiological complexity due... | null |
CRD42025637038 | What role do epigenetic modifications play in immune response and tissue healing in apical periodontitis ? | Apical Periodontitis | null |
CRD420251000404 | Does curcumin supplementation improve motor symptoms in PD patients? | Adults with Parkinson's disease (as diagnosed using any recognised diagnostic criteria). Patients on stable doses of dopaminergic medications. Curcumin; Nanocurcumin Curcumin Formulations: Studies using various curcumin formulations, such as: Nanomicelle curcumin, Curcumin phospholipids, CurQfen, Encapsulated curcumin ... | Patients with Parkinson's disease due to atypical parkinsonism, or secondary causes. Patients with severe systemic or psychological diseases. Non-curcumin Interventions: Studies that do not specifically assess the effects of curcumin or its formulations. Non-oral administration: Studies using non-oral routes of curcumi... |
CRD420250646398 | In patients with Parkinson's Disease, what is the therapeutic effect of N-acetylcysteine and Glutathione supplementation on motor and non-motor symptoms, disease markers , and disease progression, based on randomized controlled trials? | Parkinson's Disease Patients (18+ years) diagnosed with Parkinson's disease (early, moderate, or advanced stages). Human participants only. Glutathione; N-acetyl cysteine Our intervention focuses on assessing the improvement in Parkinson's disease patients across a range of outcomes following NAC and/or glutathione adm... | Studies involving populations with neurodegenerative diseases which are not Parkinson's Disease (e.g., Alzheimer's, Huntington's disease). Non-human studies (e.g., rodent models, animal studies). Studies where N-acetylcysteine or Glutathione is not the primary treatment or is combined with unrelated therapies. |
CRD420251013394 | We intend to evaluate the effects of testosterone replacement therapy on vascular function (FMD, IMT), glycemic control (FPG, HbA1c, HOMA-IR), metabolic syndrome, lipid profile, anthropometric parameters (BMI, non-HDL cholesterol),testosterone levels, and quality of life (AMS questionnaire). | Adult men (≥18 years old) with OR WITHOUT described obesity Men with Type-two diabetes mellitus Testosterone replacement therapy (TRT) in any form (e.g., injectable, transdermal, oral) Hormone Replacement Therapy; Testosterone PICO tags selected: Placebo No testosterone replacement therapy Randomized clinical trials, c... | Patients with primary testicular failure (e.g., Klinefelter syndrome) where Testosterone Replacement Therapy is not comparable to secondary hypogonadism. Men receiving Testosterone replacement therapy for non-medical purposes (e.g., bodybuilding, anti-aging). Studies where Testosterone Replacement Therapy is combined w... |
CRD42025641717 | Metabolic-associated fatty liver disease (MASLD) affects 38% of the global population and is increasingly prevalent among younger individuals. It has now become the leading cause of chronic liver disease worldwide. The economic and societal burdens associated with MASLD are substantial. Moreover, if left untreated, MAS... | Clinical practice has demonstrated that exercise interventions are an effective approach for influencing MASLD. If individuals maintain more than 60 minutes of vigorous physical activity per week, the likelihood of developing MASLD can be reduced by 42%. However, previous research findings have shown conflicting result... | null |
CRD420250570146 | Objectif principal : Décrire les expérimentations de soins pharmaceutiques développées dans la prise en charge des maladies chroniques dans les PRFI | Chronic Disease; Patient Education Adult patient with a chronic disease Education; Medication Review Done By Pharmacist; Pharmaceutical services | null |
CRD420250638727 | What are the therapeutic effects of footbath on the physical and psychological outcomes of stroke patients? | To explore scientific evidence regarding the effects of footbath on the physical and psychological aspects of stroke patients Stroke patients aged 18 years and older footbath standard care and health group | null |
CRD42023394214 | The specific review questions addressed in this review are:
1. What is the relationship between adherence and swallowing efficacy in adults with head and neck cancer (HNC)?
2. To what extent do factors influence exercise adherence variability, including intervention characteristics type i.e., direct intervention approa... | dysphagia; swallowing impairment | null |
CRD42019148022 | We want to investigate whether 6-month adjuvant trastuzumab treatment is non-inferior to the standard 12-month treatment in women with HER2-positive early breast cancer. | Adjuvant trastuzumab apparently improves outcomes for women with HER2-positive early breast cancer. The standard treatment duration is 12 months, but recent studies show that shorter treatments may provide similar efficacy while reducing toxicities and cost. | null |
CRD42018088739 | What is the effect of extended anticoagulant therapy for VTE on clinically relevant outcomes including all-cause mortality, thromboembolic mortality, cardiovascular mortality and major bleeding-related mortality? | Venous thromboembolism (VTE), mortality, and anticoagulant therapy. | null |
CRD42024559904 | P: Pediatric and adults patients with osteosarcoma and acute lymphoblastic leukemia and lymphoma malignanciesI : Therapeutic and pharmacological monitoring of methorexate ( dosage analysis and adjustement ) C : NoneO : Dosage adjustment and administration of antidotes for better efficacy and avoiding toxicities | Osteosarcoma Of Bone; Non-hodgkin's Lymphoma; Acute Lymphoid Leukemia Methotrexate is used to effectively treat pediatric and adult patients with acute lymphoblastic leukemia, osteosarcoma, and lymphoma malignancies.However, it has been associated with toxic effects, including acute kidney injury,, hepatotoxicity, and ... | null |
CRD42024492640 | What is the effectiveness of non medical interventions to increase empathy in adults on the Autistic Spectrum.
Population: Adults diagnosed with Autistic Spectrum Disorder.
Intervention: Non-medical interventions that aim to increase empathy.
Comparison: Control groups/active control groups.
Outcome: Post empathy score... | Studies must have recruited participants with a diagnosis of Autistic Spectrum Disorder using recognised psychometric assessments and clinical interview as specified in the recognised classification systems of Diagnostic and Statistical Manual (DSM) 4 and 5, and International Classification of Diseases (ICD) 10 and 11.... | null |
CRD42025640905 | Disorders of consciousness present a significant challenge in clinical practice due to their complex nature and variability in outcomes. Predictive models are critical for guiding treatment decisions and setting realistic expectations for recovery, but their accuracy and applicability remain unclear. This review aims t... | Disorders of consciousness (DOC) encompass a spectrum of conditions characterized by impaired awareness and responsiveness, including coma, vegetative state, and minimally conscious state. These conditions often result from severe brain injuries such as trauma, stroke, or hypoxia. The review focuses on the healthcare d... | null |
CRD42023482063 | How do Umbilical cord Mesenchymal Stem Cells and Bone marrow Mesenchymal Stem Cells differ as regenerative therapeutic modalities for heart therapy ? | Heart failure, Myocardial infarction, Mesenchymal stem cells in heart therapy | null |
CRD420251018557 | To compare the differences in the effects of aerobic exercise and resistance exercise on the pulmonary function (FEV1%, FEV1/FVC), exercise tolerance (6MWT) and quality of life (SGRQ score) of elderly patients with COPD. | Patients with Chronic Obstructive Pulmonary Disease (COPD) Aerobic Exercise PICO tags selected: Resistance training | null |
CRD42023393570 | We aim to determine if embryonic stem cells transplantation therapy can significantly improve the prognosis and outcome of patients with traumatic brain injury (TBI) and traumatic spinal cord injury (TSCI), and have the potential to be a viable and sustainable treatment option for neurotrauma.
The PICO structure was us... | Traumatic brain injury (TBI) and traumatic spinal cord injury (TSCI) | null |
CRD42020155575 | This review aims to evaluate the performance standards and role of imaging for whole-body MRI due to the presence of myeloma, as proposed by the Myeloma Response Assessment and Diagnosis System (MY-RADS). | Whole-body MRI in myelomva | null |
CRD42024526281 | Research Question:
"In a randomized controlled meta-analysis, how does the efficacy of coenzyme Q10 supplementation compare with that of nanocurcumin in alleviating the clinical symptoms of migraine patients within the field of non-pharmacological treatment?"
Research Objectives/Purpose:
The primary objectives of this ... | This research focuses on the non-pharmacological treatment of migraine, specifically exploring the comparative effectiveness of supplemental turmeric (curcumin) and coenzyme Q10 in alleviating the clinical symptoms of migraine. Our study is a randomized controlled meta-analysis comparing supplemental coenzyme Q10 and n... | null |
CRD42024589096 | The aim of this meta-analysis is to evaluate the efficacy and safety of the combination therapy of semaglutide and metformin in Chinese patients with type 2 diabetes, with a focus on glycemic control and treatment-related adverse events, in order to optimize therapeutic strategies specific to this population. | Health outcomes for type 2 diabetes typically include glycemic control, complication rates, quality of life, and long-term survival. Effective management of type 2 diabetes can reduce the risk of complications such as cardiovascular disease, nephropathy, retinopathy, and neuropathy. Key health indicators include glycat... | null |
CRD42022340996 | • Generic question: What sort of endocrinologic follow-up is recommended to monitor the onset of endocrinologic diseases in NKX2-1-related disorders?
• Structured question: What are the best procedures for initial screening of endocrine diseases in patients with NKX2-1-related disorders? | NKX2-1-related disorders (brain-lung-thyroid syndrome) are characterized by choreoathetosis, hypothyroidism, and neonatal respiratory distress caused by variants or deletions of the NKX2-1 gene. The Systematic Review focuses on the best procedures for the early detection of endocrine diseases in patients with NKX2-1-re... | null |
CRD420251029765 | The purpose of this review is to evaluate the role of colchicine | Adult patients aged 18 years and above with any cardiovascular disease (CVD) who receive colchicine. Colchicine administration as monotherapy or in combination with other standard therapies PICO tags selected: Placebo Standard treatment without colchicine or placebo. Studies including RCTs and observational studies wil... | Patients younger than 18 years old, patients not rececing colchicine and patients using colchicine for noncardiovascular reasons. Patients not receicing colchicine or any other therapy for cardiovacular conditions. Patients not receiving any therapy at all. Case report, case series,editorial and opinion articles will b... |
CRD420250653697 | P：Breast Cancer
I: Mind-Body-Exercise
C: Passive control, usual care and standard therapy
O: QoL and Fatigue
S: RCT | Fatigue plays a central role in the reduced quality of life of breast cancer patients. This form of cancer-related fatigue is closely linked to the HPA axis and the immune system. Chronic stress leads to excessive activation of the hypothalamic-pituitary-adrenal (HPA) axis, increasing cortisol release. Persistent immun... | null |
CRD42023447554 | Is McKenzie exercises are effective for reducing the symptoms of forward head posture | FHP is a severe condition that has risen in frequency recently. The head moves forward, shifting the Centre of gravity. The head is placed in front of the trunk as the upper body recedes and the shoulders drop forward in order to make up for the change in the Centre of gravity. A forward neck posture is one in which th... | null |
CRD420250629268 | Population: The present review will include human clinical trials with a 6-month minimum follow-up.The participants included are those diagnosed with periodontitis stage III and IV, grade B or C, not medically compromised, and older than 18 years. The definition of periodontitis will be based on the latest 2017 Classif... | Periodontitis The present review will include human clinical trials with a 6-month minimum follow-up.The participants included are those diagnosed with periodontitis stage III and IV, grade B or C, not medically compromised, and older than 18 years. The definition of periodontitis will be based on the latest 2017 Class... | null |
CRD42024506012 | Can Retinal Vessel diameter changes predict the incidence and progression of diabetic retinopathy？
Can the retinal vessel diameter be used as an index to evaluate the therapeutic effect of diabetic retinopathy?
We included studies that explored the correlation of retinal vessel diameter with diabetic retinopathy aimed ... | Diabetic retinopathy (DR) is an ocular lesion caused by retinal microvascular damage caused by diabetes. As the first blind eye disease in working age people, blindness and low vision caused by DR has become a major public health problem, and its early prevention and treatment is the focus and difficulty of clinical pr... | null |
CRD42023423567 | I. To describe clinical characteristics, risk factors and outcomes of adult patients with hepatitis caused by Herpes simplex Virus
II: To describe laboratory characteristics and risk factors of adult patients with hepatitis caused by Herpes simplex Virus | Hepatopathy caused by herpes simplex virus types 1 or 2. | null |
CRD420251040979 | To assess the prevalence of anemia among patients with heart failure (HF). | Human adults diagnosed with heart failure (acute or chronic) and anemia, with clearly defined diagnostic criteria for both conditions, across all clinical settings Heart Failure Education; Anemia Screening; Hospital admission | null |
CRD420251005555 | null | patients with esophageal cancer confirmed by pathological diagnosis, with no exclusion based on gender, age, or clinical stage Carboplatin; Paclitaxel; Chemotherapy PICO tags selected: Cisplatin; Fluorouracil; Chemotherapy randomized controlled trial (RCT), meeting summaries, abstracts, cohort study, or case-control st... | Reviews, single case reports, expert consensuses, or editorials |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.