Study_ID string | Objectives string | Included string | Excluded string |
|---|---|---|---|
CRD42024598899 | Review Question
This meta-analysis seeks to answer the following primary and secondary questions:
1. Primary Question
What are the comparative effects of Optimal Load Power Training versus Traditional Strength Training on power output and muscle strength in healthy adults?
2. Secondary Questions
Does the effect of Opti... | This systematic review focuses on strength training, specifically comparing Optimal Load Power Training with Traditional Strength Training in healthy adults. The study aims to explore the effects of these different training methods on power output, muscle strength, and explosive performance (e.g., vertical jump, sprint... | null |
CRD42022308020 | Does radiotherapy conditioning impact on outcomes in patients treated with CAR-T therapy for high grade lymphoma?
Does the use of combination therapy with radiotherapy and CAR-T result in an altered side effect profile? | The goal of this review is to determine the impact of radiation augmentation prior to CAR-T cell therapy on the outcomes in patients with high-grade lymphoma. | null |
CRD42024585906 | The purpose of this study is to systematically evaluate the effectiveness and safety of Shengmai decoction preparations in the prevention and treatment of cardiovascular diseases, and initially explore its mechanism of action and methodological limitations, so as to provide references for clinical rational drug use in ... | Cardiovascular disease is one of the major health problems in the world today, its morbidity and mortality remain high, seriously threatening human health and life. According to the World Health Organization, about 17.9 million people die from cardiovascular disease each year, accounting for 31% of all deaths. Cardiova... | null |
CRD42023481382 | To date, no direct comparisons have compared the effectiveness of all EGFR-TKIs against EGFR mutation-positive non-small cell lung cancer (NSCLC). The present study aimed to investigate the efficacy and safety of EGFR-TKIs in EGFR mutation-positive NSCLC. | Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer, and a significant proportion of patients with NSCLC have epidermal growth factor receptor (EGFR) mutations. The most common EGFR mutations are exon 19del and exon 21 L858R, and these are associated with sensitivity to EGFR tyrosine kinase... | null |
CRD42023458529 | Define the burden, natural history and outcomes of Crohn’s disease and ulcerative colitis in Africa. | The epidemiology of inflammatory bowel disease has been extensively explored in developed countries in contrast to less developed regions. Over recent years, a noticeable rise in the occurrence of inflammatory bowel disease has been observed in sub-Saharan Africa, Asia, and South America, as indicated by recent reports... | null |
CRD42024536421 | Impact of vitamin D supplementation on chronic kidney disease patients? | People with CKD | null |
CRD420250597781 | Does neurofeedback therapy impact cognitive function in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared to standard care or no treatment? | Mild Cognitive Impairment; Alzheimer's Disease Studies meeting the following inclusion criteria will be considered: Participants diagnosed with Alzheimer's disease and Mild Cognitive Impairment (MCI) according to internationally recognized diagnostic criteria. Studies examining the relationship between neurofeedback th... | null |
CRD420250652869 | This study aims to investigate the efficacy and safety of therapeutic plasma exchange (TPE) for treating patients with autoimmune neurological diseases. | Neurological Impairment; Autoimmune Disease; Guillain-barre Syndrome; Myasthenia Gravis; Plasma exchange Autoimmune neurological diseases are a group of disorders caused by abnormal immune responses, including Guillain-Barré syndrome (GBS), neuromyelitis optica spectrum disorders (NMOSD), myasthenia gravis (MG), and st... | null |
CRD42023479965 | Main Review Question:
What are the diagnostic accuracies (sensitivity, specificity, positive predictive value, and negative predictive value) and the overall diagnostic value (such as the area under the receiver operating characteristic curve) of different physiological, biochemical, immunological, and microbiological ... | This review focuses on sepsis, a critical condition caused by the body's dysregulated response to infection, leading to severe systemic inflammation and organ dysfunction. Despite medical advances, sepsis remains a global health challenge with rising incidence and mortality. Its heterogeneity presents varied clinical m... | null |
CRD42025646111 | Upon determining if there is substantial evidence to support the belief that juvenile-onset RRP (JoRRP) presents more aggressively than adult-onset RRP (AoRRP), which risk factors contribute to this difference? Across the clinical course of RRP, how does the severity of the disorder fluctuate long-term for JoRRP vs. Ao... | Recurrent respiratory papillomatosis (RRP) is a disease characterized by the growth of benign papillomas/tumors in the respiratory tract, especially the larynx. It is most caused by HPV 6 and 11.
Symptoms include dysphonia and airway obstruction. | null |
CRD42024520051 | A Critical Overview of Systematic Reviews and Meta-Analyses of Natural Orifice Transluminal Endoscopic Surgery(NOTES) for treatment of surgical diseases. | Surgical diseases require surgery or manipulation as the main means of treatment . They are divided into five major categories: trauma, infection, tumor, deformity and dysfunction. Therefore, surgery has become a unique treatment method of surgery. In order to achieve greater benefits for patients and the healthcare sy... | null |
CRD420251034942 | This systematic review aims to evaluate the diagnostic accuracy, treatment efficacy, and clinical outcomes of esophageal perforations following anterior cervical spine surgery in adults. Specifically, it will assess which diagnostic methods (imaging, endoscopy, clinical signs) most reliably detect perforations; compare... | oesophageal perforations after anterior spinal surgery Surgery Inpatient Care Management Initial investigation and management of esophageal perforations. | without anterior cervical spinal surgery |
CRD42025640451 | Primary Questions:
In patients undergoing bronchoscopy, how does Remimazolam compare to Dexmedetomidine in terms of procedural success rates?
How does Remimazolam compare to Dexmedetomidine regarding safety outcomes, including the incidence of bradycardia, tachycardia, hypoxia, hypotension, hypertension, and postoperat... | Domain: Procedural Sedation in Respiratory Medicine
Description: Evaluation of sedation strategies to ensure effective and safe sedation during diagnostic and therapeutic bronchoscopy, focusing on comparing two distinct sedative agents: Remimazolam (an ultra-short-acting benzodiazepine) and Dexmedetomidine (an alpha-2 ... | null |
CRD42023457925 | Primary Question:
What is the effectiveness of acupressure and acupuncture in reducing pain and anxiety and improving outcomes in patients undergoing coronary angiography or percutaneous coronary intervention?
Secondary Questions:
What is the effect of acupressure and acupuncture on systolic blood pressure (SBP) in pat... | Coronary angiography and percutaneous coronary intervention (PCI) are common procedures used in the diagnosis and treatment of coronary artery disease (CAD), a leading cause of morbidity and mortality worldwide. While these procedures are necessary, they can be associated with significant levels of pain, anxiety, and p... | null |
CRD42025623875 | Taking “How does traditional Chinese medicine treatment compare with no treatment or conventional Western medicine treatment in terms of its effects on improving muscle mass, muscle strength, and physical function in patients with sarcopenia?” as the writing framework, this research is carried out as a network meta-ana... | This registered systematic review focuses on the field of sarcopenia. It is a syndrome caused by aging, characterized by decreased skeletal muscle mass, muscle strength and/or physical activity function. It will affect the lives of the elderly and increase many risks. Modern medicine commonly uses nutritional support a... | null |
CRD42023486399 | Population: Premature infants presenting with Retinopathy
Intervention: Different anti-VEGF therapies (bevacizumab, aflibercept etc.)
Control: Laser photocoagulation
Outcomes: Ocular safety measure by retreatment rate, retinal detachment, time to retreatment, while efficacy will be assessed by reduction in myopia and a... | Retinopathy of prematurity is a disorder of retinal vasculature affecting pre-term infants. It is one of the leading causes of childhood preventable blindness, resulting from retinal neovascularization. | null |
CRD420250653365 | The management of Rheumatoid Arthritis-associated Interstitial Lung Disease (RA-ILD) presents a significant therapeutic challenge due to the expanding array of treatment options, including conventional DMARDs, biological agents, antifibrotic drugs, and various combination therapies. While multiple randomized controlled... | Recent years have witnessed increasing diversification in therapeutic approaches for Rheumatoid Arthritis-associated Interstitial Lung Disease (RA-ILD), evolving from conventional glucocorticoids and immunosuppressants to novel biological agents and targeted therapies, thereby expanding the therapeutic arsenal availabl... | null |
CRD420250631714 | In adult patients with COPD or chronic asthma, does an intervention based on the application of biofeedback, compared to sham treatment and standard treatment, lead to a reduction in stress and psychological distress, an improvement in respiratory function, and a better quality of life? | Asthma exacerbation; COPD Exacerbation Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and chronic asthma, are characterized by marked airflow limitation and impaired lung capacity. These conditions frequently manifest with debilitating symptoms, such as persistent breathing difficult... | - Studies including patients with other diseases - Other patients with other chronic respiratory diseases (tumour; fibrosis) - Non-pharmacological treatments other than biofeedback - Studies that do not separate the effects of biofeedback from other therapeutic interventions without a clear control group. - Minors - Ar... |
CRD42020193289 | compare and rank different moxibustion methods to see which treatment is most effective for lumbar disc herniation | Lumbar disc herniation is a clinical common disease and frequently-occurring disease with waist pain as the main symptoms, the intervertebral disc degeneration, bulgin, herniated and stimulation and oppressive nerve root and horsetail nerve is its pathogenesis, the disease can occur as the disease progresses gradually ... | null |
CRD42021224750 | The aim of this meta-analysis is to evaluate the efficacy and safety of 5 fluorouracil-based adjuvant therapy for resected biliary tract cancer. | Bile duct cancer (starting in the bile duct) is an uncommon malignant tumour.The benefit of 5-fluorouracil based adjuvant therapy for biliary tract cancer is unclear, with conflicting results from nonrandomized studies. | null |
CRD420250655600 | What are the contemporary therapeutic interventions for balance rehabilitation of children with down syndrome? | Neurological Diseases ( e.g. Down Syndrome ) Children with neurological diseases (e.g. Down Syndrome) Contemporary Therapeutic Interventions Conventional Therapy or Non-exposed Control Group. | null |
CRD420250656551 | 1. What are the novel biomarkers discovered through metabolomics and proteomics that are linked to the onset and progression of chronic complications in diabetes mellitus?2. Which pathways play central role in the onset and development of these complications? | Diabetes mellitus (DM) is a significant global health concern. It is a major contributor to a broad spectrum of chronic diseases, including microvascular complications (retinopathy, nephropathy, neuropathy), and macrovascular complications (cardiovascular diseases, peripheral artery disease, and cerebrovascular acciden... | null |
CRD42024513738 | The objective of this systematic review and meta-analysis is to evaluate the efficacy, oncologic safety, and optimal timing of staged nipple-sparing mastectomy (NSM) following nipple repositioning surgery (mastopexy or breast reduction) in patients with large or ptotic breasts. | Mastectomy; Breast Cancer; Reduction Mammoplasty Prophylactic or oncoplastic nipple-sparing mastectomy in ptotic breasts following mastopexy or breast reduction Patients with enlarged or ptotic breasts who undergo nipple sparing mastectomy following mastopexy or breast reduction Bilateral Reduction Mammoplasty; Reducti... | null |
CRD420250655762 | How cytotoxic t cells- derived exosomes exert cytotoxicity against cancer? | Cancer All animal species and cell lines | Cancer therapy without using TCD8-derived exosome |
CRD42020160460 | Does specific parasites and their component have a protective effect on the severity and prognosis of Systematic lupus erythematosus (SLE)?
Population:animal model of SLE
Intervention: intervention with live parasite or synthetic parasitic component
Comparison: no intervention with live parasite or synthetic parasitic... | systematic lupus erythematosus (SLE) All lupus-prone animals (Mice, Rat, Hamster or any others), with any gender or age groups who received any parasitic antigens for treatment systematic lupus erythematous. All component derived from helminths, protozoans, or intervention with any parasitic antigens along with compara... | Animals with other autoimmune diseases like rheumatoid arthritis will be excluded. therapeutic interventions like bacterial and viral interventions will be excluded. any other control group without non-exposed controls and placebo groups. |
CRD42020190300 | What are the current treatment options for COVID-19? | The COVID-19 pandemic is a serious global health threat.
Symptoms may appear 2-14 days after exposure to the virus, which can be fever or chills, cough, shortness of breath or difficulty breathing, fatigue, muscle or body ache, headache, the new loss of taste or smell, sore throat, congestion or runny nose, nausea or v... | null |
CRD420250596885 | Our health care question was defined a priori using the PICOS (Population, Intervention, Comparator, Outcomes, and Study design) format. Population: male and female patients >18 years old with chronic kidney disease (CKD). Intervention: patients with CKD were treated by stem cell therapy. Comparison: not available or s... | Chronic Kidney Disease; Stem Cell Therapy Chronic kidney disease (CKD) is a global health problem that is associated with an age-related impairment of renal function, which can be exacerbated by several risk factors such as diabetes, hypertension, heart disease, and a family history of kidney failure. Stem cells based ... | Exclusion: Under 18 years of age |
CRD42025641451 | Do injectable hydrogel formulations containing cisplatin exhibit antitumor effects on breast cancer in both in vitro and in vivo studies | Breast Neoplasms all animal models with experimental cancer in which metastasis can develop (all species, all sexes). Studies must involve the administration of injectable hydrogels as a delivery system for cisplatin.
Hydrogels used must allow localized, sustained release of cisplatin. free injectable hydrogel control ... | animals with co-morbidities • Studies that do not specifically evaluate cisplatin-loaded hydrogels as an intervention.
• Studies where the hydrogel formulation is not injectable or does not involve localized delivery of cisplatin. all other control conditions |
CRD420251002547 | To evaluate and compare the efficacy (BRMS reduction, response rates) and safety (adverse events) of quetiapine monotherapy versus its combination therapies (valproate salts, lamotrigine, lithium, MECT) for bipolar manic episodes. This network meta-analysis aims to rank interventions, identify optimal regimens, assess ... | Adults (≥18 years) with bipolar manic episodes diagnosed by DSM-5/ICD-11 criteria. Quetiapine Quetiapine alone or in combination with other therapies PICO tags selected: Quetiapine Quetiapine monotherapy or conventional therapy or placebo. | Comorbid severe physical diseases (e.g., renal insufficiency) or other psychiatric disorders (e.g., schizophrenia). Quetiapine combined with non-target therapies. |
CRD42024609978 | This systematic review aims to comprehensively evaluate the clinical efficacy and safety of Rilonacept in treating recurrent pericarditis. The primary research question addresses whether Rilonacept demonstrates superior therapeutic outcomes compared to standard treatment or placebo in patients with recurrent pericardit... | Recurrent pericarditis is characterized by repeated episodes of pericardial inflammation following an initial acute episode, with recurrence defined as the return of symptoms after a minimum symptom-free interval of 4-6 weeks. The condition affects the pericardium, the fibrous sac surrounding the heart, and manifests p... | null |
CRD42023457311 | Does licorice has effect on oral mucositis patients in both men or women with history of any type cancer treated with chemotherapy or radiotherapy? | improvement on pain scale and grading of oral mucositis. | null |
CRD42021265957 | AIM 1: To compare and evaluate the clinical outcomes after angioplasty in diabetic and non-diabetic patients.
AIM 2: To observe antiplatelet therapy after angioplasty in diabetic and non-diabetic. | Therapeutic clinical outcome after angioplasty in diabetic and non-diabetic | null |
CRD420251000153 | What are the effects of proprioceptive exercise on postural balance in people with anterior cruciate ligament reconstruction? | individual with unilateral Anterior Cruciate Ligament (ACL) Reconstruction: This includes both male and female individual who have undergone surgery for ACL injuries Virtual Reality; Proprioceptive Exercises; Physical Exercises Intervention involves the use of Proprioception and Virtual Reality PICO tags selected: Plac... | In the reports, in addition to a previous anterior cruciate ligament injury, the participants also had other injuries to the knee area. Control criteria not met Postintervention results not report Systematic reviews, meta-analysis, Ph.D. thesis, case studies, comments |
CRD42024562111 | The disease is chronic obstructive pulmonary disease , the intervention measures are different chinese patent medicines, and the research method is randomized control. | Chronic Obstructive Pulmonary Disease (COPD) is a disease caused by chronic bronchitis and emphysema, characterized by persistent airflow restriction and respiratory symptoms , with further aggravation leading to pulmonary heart disease and respiratory failure. It has become the fourth most deadly disease in the world.... | null |
CRD420251019839 | To systematically review and synthesize existing literature on marginal zone lymphoma (MZL) presenting with skeletal (bone) involvement and/or hypercalcemia, with the aim to: | Inclusion criteria: Diagnostic imaging; Chemotherapy; Bisphosphonates; Denosumab This review focuses on exposure rather than intervention. Included studies must describe cases of marginal zone lymphoma (MZL) with either: The review will include patients regardless of specific treatment received, but will record interv... | Exclusion criteria: |
CRD420251005386 | This systematic review aims to evaluate the effectiveness of artificial intelligence (AI), including machine learning and deep learning methods, in the interpretation of 2D transthoracic echocardiographic (TTE) images for the assessment of acute cardiovascular conditions. Specifically, the review seeks to determine whe... | Adults (≥18 years old) undergoing transthoracic echocardiography (TTE) for urgent cardiac assessment. Patients with acute cardiovascular conditions, including cardiogenic shock, myocardial infarction, acute heart failure, and suspected pericardial effusion. Artificial intelligence; Point Of Care Testing Application of ... | Pediatric patients (<18 years old) and studies involving animal models. |
CRD42022299464 | Biliary drainage aims to lower the hyper bilirubinemia, either to relieve jaundice related symptoms or to enable administration of systemic therapy. Different modalities are available for biliary drainage such as endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic cholangiography (PTC) and ... | However, stents only play a role in drainage with no inhibitive effect on tumors, and might induce an in-stent restenosis or obstruction in a long run, which has been a key factor affecting the therapeutic efficacy. Some scholars treated malignant biliary tract obstruction with stent combined with radiotherapy or chemo... | null |
CRD42024495119 | What are the characteristics of reported Allergic Fungal Rhinosinusitis (AFRS) cases in the Eastern Mediterranean Region regarding clinical presentations, diagnostic criteria, treatment methods, and outcomes? What are the fungi involved in AFRS in the Eastern Mediterranean region? Are the types of causative fungi relat... | Allergic fungal rhinosinusitis (AFRS) is a type of chronic rhinosinusitis with nasal polyps (CRSwNP). It's distinguished by heightened sensitivity to antifungal IgE, mucus rich in eosinophils (allergic mucin), and distinct imaging results on computed tomography and magnetic resonance imaging in the sinuses. AFRS manife... | null |
CRD42022337769 | Does carrying certain mitochondrial mutations increase the risk of developing sensorineural hearing loss after exposure to aminoglycosides in humans? | Aminoglycosides are an important class of antibiotics in our therapeutic arsenal against aerobic Gramnegative bacteria, such as Pseudomonas spp. and Enterobacteriaceae. They are also important drugs in the
treatment of multidrug-resistant tuberculosis. However, ototoxicity associated with aminoglycoside use is a
recogn... | null |
CRD42019128168 | This study evaluated the effectiveness of fire needle in the treatment of nodular prurigo to determine whether fire needles are worthy of promotion. | Conventional treatments for nodular prurigo are not suitable for patients with a large number of lesions, which are likely to relapse. Fire needle therapy is a traditional treatment that stimulates the meridians, dredges the meridians and collaterals, and accelerates the flow of Qi and blood, consequently dissipating t... | null |
CRD42021254527 | Does Botulinum Toxin Type A help in the treatment of Myofascial Pain Syndrome? | Myofascial pain syndrome (MPS) is a regional pain disorder caused by taut bands of muscle fibers in skeletal muscles called myofascial trigger points. MPS is a common disorder, often diagnosed and treated by physiatrists. | null |
CRD42024580482 | Sarcopenia is an age-related syndrome of muscle quality, strength, and function decline, with current prevalence rates of 12.3% in urban Chinese men and 4.8% in women, 6.4% in rural Chinese men and 11.5% in women. With the aging crisis worsening, the prevalence of sarcopenia is increasing, which may lead to a decline i... | Sarcopenia is an age-related syndrome characterized by progressive loss of muscle mass, muscle strength, and/or physical function (ICD-10 code M62.84). Its features include decreased muscle mass, decreased muscle strength, and/or impaired physical function. The latest version of the Asian Sarcopenia Diagnosis and Treat... | null |
CRD42023448069 | The present study aims to investigate the impact of resveratrol on oral neoplastic parameters through a systematic review and meta-analysis. | The present study aims to investigate the impact of resveratrol on oral neoplastic parameters through a systematic review and meta-analysis. | null |
CRD420251029187 | Review Objectives | Inclusion Criteria (Population) Human Subjects: Studies involving patients of any age or gender diagnosed with oral cancer, particularly oral squamous cell carcinoma (OSCC). Studies involving patients with precancerous oral lesions (e.g., leukoplakia, erythroplakia, oral submucous fibrosis) will also be included if the... | Exclusion Criteria (Population) Studies on non-oral cancers (e.g., lung, breast, prostate, etc.). Healthy populations without any focus on oral cancer prevention or treatment. Studies involving non-phytochemical interventions (e.g., synthetic drugs without plant origin). Populations with multifactorial or mixed-type ... |
CRD42020192440 | The objective of the current review is to conduct a systematic literature review (SLR), with a focus on studies investigating therapeutic regimens in patients with relapsed or refractory multiple myeloma (RRMM) who have received as part of their previous therapy an immunomodulatory agent (IMiD), proteasome inhibitor (P... | The condition of interest is RRMM. Multiple myeloma (MM) accounts for 1% of all cancers worldwide and approximately 10% of hematological neoplasms. In the European Union (EU) and the US, approximately 50 000 patients are diagnosed with MM and 30 000 patients die due to MM each year. Modern treatment plans focus on incr... | null |
CRD420251020743 | The effect of Tai Chi intervention on people with fatigue | Adults suffering from fatigue symptoms Tai Chi PICO tags selected: Usual Care | null |
CRD420251001926 | 1. What are the short-term and long-term outcomes of different treatment options for trigger finger? | patient with trigger finger at any severity Injection; Splint; Surgery; Extracorporeal Shock Wave Therapy PICO tags selected: Surgery; Exercise therapy | nil |
CRD42020160959 | To identify the impact of sedentary behaviors on the risk of depression | Depression is a common mental disorder and major human blight that affects up to 25% of women and 12% of men. According to the World Health Organization, around 350 million people had suffered from depression in 2010. Specific clinical and therapeutic features for depression have been described in childhood and the eld... | null |
CRD42023391773 | In this systematic review and meta-analysis, we intend to conduct qualitative and quantitative analyzes of randomized controlled trials (RCTs) in which therapeutic exercise was performed on sarcopenia in community-dwelling older adults. | Community-Dwelling Elderly with Sarcopenia | null |
CRD42021297098 | This study was carried out to provide evidence-based recommendations on the efficacy of all currently clinically used pharmacological treatments for mania. | Bipolar disorder is a mental illness that is highly likely to result in severe dysfunction and a high state of mind. Pleasant and joyful; racing thoughts; accelerated association processes; psychomotor excitement, and accompanied by severe social problems and physical and mental impairment. The lifetime prevalence of m... | null |
CRD42024605435 | Are 5HT2A receptor agonists effective in reducing depressive symptoms in patients with treatment-resistant depression? | Treatment-resistant depression (TRD) refers to major depressive disorder that does not respond adequately to at least two different antidepressant treatments. This condition is associated with severe symptoms, impaired functioning, and poor quality of life. Recent interest has emerged in the potential role of 5HT2A rec... | null |
CRD42021278977 | To systematic review the efficacy of moxibustion for menstrual irregularities. | menstrual irregularities.Irregular menstruation is a common clinical gynecological disease.The treatment based on moxibustion has less side effects and higher safety factor than the routine treatment of western medicine. | null |
CRD42024627816 | 1. What factors contribute to bacterial vaginosis (BV), such as the impact of fluctuating hormone levels, lifestyle differences, and environmental factors? (Etiology aspect - Exposure)
2. How does the imbalance in the vaginal microecology and overabundance of pathogenic bacteria lead to the start, progression, and rela... | The condition being studied is bacterial vaginosis (BV). Bacterial vaginosis is a common vaginal infection. It is mainly characterized by an imbalance in the vaginal microecology with an overgrowth of pathogenic bacteria. Factors like fluctuating hormone levels, differences in lifestyle, and various environmental aspec... | null |
CRD42024552021 | Can interventions change the big five personality traits? | Big five Personality changes. Evaluation of Results of Therapeutic Interventions | null |
CRD420250631239 | Can exosomal microRNAs be utilized as therapeutic tools to mitigate or reverse the pathological processes associated with Alzheimer’s disease? | Alzheimer's disease Animal studies on Alzheimer’s disease in rats and mice, focused on amyloid beta pathology and/or tau hyperphosphorylation and/or behavior tests for learning and memory. Treatment using exosomes carrying miRNA; no restriction will be applied on duration, route of administration, and dose of treatment... | Clinical, ex vivo, in vitro, and in silico studies. Using miRNA and exosomes as diagnostic tools. - Animals not modeled for Alzheimer's disease, not receiving exosomal microRNAs.- Animals not modeled for Alzheimer's disease, receiving exosomal microRNAs |
CRD42021286575 | In the treatment of unresectable hepatocellular carcinoma, randomized controlled trials of four first-line treatment regimens were found based on pre-defined search terms "sorafenib, lenvatinib, sintilimab plus bevacizumab, atezolizumab plus bevacizumab". | Liver cancer remains a global health challenge and its incidence is growing worldwide. It is estimated
that, by 2025, >1 million individuals will be affected by liver cancer annually. Hepatocellular carcinoma
(HCC) is the most common form of liver cancer and accounts for ~90% of cases. | null |
CRD42024590945 | Can insulin resistance in an isolated organ be considered "in situ diabetes"? | While peripheral insulin resistance (IR) has been extensively investigated, our understanding of organ-specific IR remains limited. Thus, we propose the term "in situ diabetes mellitus," or “type 6 diabetes mellitus” (T6DM) where individual organs develop IR independently of systemic metabolic disturbances. This knowle... | null |
CRD42020196452 | To compare and rank several active immunotherapeutic approaches in the treatment of malignant melanoma to better inform clinical practice. | Melanoma with a high somatic mutation frequency, is one of the most aggressive and life-threatening solid tumors and associated with a poor prognosis. | null |
CRD420251035859 | Objective: | Adults aged 18 years and older Wheelchair athletes (e.g., wheelchair basketball, rugby, tennis, badminton, seated volleyball) Diagnosed with spinal cord injury (e.g., paraplegia, tetraplegia) Experiencing shoulder pain or shoulder-related musculoskeletal complaints Participants involved in competitive or recreational w... | Non-athletic wheelchair users Participants with other neurological or musculoskeletal conditions not related to spinal cord injury Studies focusing on children or adolescents (under 18 years) Studies not reporting on shoulder-related outcomes Studies not available in English or German Studies focusing solely on surgica... |
CRD420250621318 | Does Centella asciatica and Bacopa Monnieri improve cognitive function by reducing the oxidative stress in Alzheimer’s disease? | Alzheimer's disease (AD) is a progressive neurological condition and the predominant kind of dementia, representing 60–80% of cases worldwide. It is clinically defined by a progressive deterioration in cognitive abilities, memory deficits, disorientation, and behavioral problems. The neuropathological characteristics o... | Non – animal studies Animal models of cognitive impairment not directly related to Alzheimer's disease Animas with balance and locomotor problems Animals with scars and wounds Studies without a control group for comparison. Studies comparing effects only between Centella asiatica and Bacopa monnieri, without a disease ... |
CRD42024516129 | This systematic review aims to assess both oncological and toxicity impact of "augmented radiotherapy", including either dose escalation or target volume escalation, for the management of high-risk prostate cancer. | This systematic review focuses on high-risk prostate cancer patients, receving "augmented radiotherapy" as upfront treatment. Augmented radiotherapy is defined with either escalation on dose delivered on the prostate gland (>78Gy) or escalation of irradiated target volumes. | null |
CRD42020218963 | Which is the preferable method to evaluate mid-sagittal reference plane for the analysis of facial asymmetry? | Facial asymmetry or craniofacial deformity | null |
CRD42021281950 | What is the level of evidence in the literature about interventions or agents that target non-nervous gut microbiota to modulate stroke outcome in animal model of stroke disease? | Stroke. Studies that involve animal stroke model either in lower or higher animals. Studies that use at least one intervention or agent or therapy of any kind to effect stroke via microbiota gut-brain axis. The comparator will be groups of animal that have not received intervention either as sham (pseudo stroke inducti... | Studies that involve animal stroke model without control group, as well as stroke models involving in vitro, ex vivo, or in silico studies. Studies that do not use any intervention to effect stroke via microbiota gut-brain axis. Study will also be excluded if intervention is not directly administered to the tested popu... |
CRD42023482389 | Is injecting '5% dextrose' in patients with 'carpal tunnel syndrome' superior to injecting the traditional 'steroid' in terms of 'pain reduction and functional recovery'? | Carpal Tunnel Syndrome (CTS) is a neurological disorder caused by compression of the median nerve within the carpal tunnel, located in the center of the wrist. It manifests with symptoms such as pain, numbness, and muscle weakness in the palm and fingers. CTS affects many individuals in their daily lives, particularly ... | null |
CRD42022375023 | What are the effects of mindfulness-based interventions on executive function in healthy adults? | Executive function in healthy adults. | null |
CRD420250643566 | Do patients with VEXAS syndrome have an elevated risk of infection?Population (P): Patients with a confirmed diagnosis of VEXAS syndrome, verified by the presence of a UBA1 gene mutation.Intervention (I): Glucocorticoids, azacitidine, anti-IL-1 agents, IL-6 inhibitors, anti-TNF agents, or allogeneic hematopoietic stem ... | VEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a rare disorder caused by somatic mutations in the UBA1 gene. It typically manifests in late adulthood with systemic inflammation, hematologic abnormalities, fevers, arthralgia, skin rashes, and cytopenias. Patients often require immunosuppres... | null |
CRD42022304580 | 1. What is the magnitude of trauma cue-induced drug craving among substance users with trauma histories or PTSD relative to A) baseline drug craving; B) neutral cue-induced drug craving; C) substance cue-induced drug craving; and D) stress cue-induced drug craving?
2. Is the magnitude of trauma cue-induced drug craving... | Comorbid PTSD/trauma history and substance use. | null |
CRD420250624140 | Is systemic alendronate able to improve clinical parameters of periodontitis without causing osteonecrosis? | Periodontitis is a chronic inflammatory disease with a multifactorial etiology that culminates in the progressive destruction of the tooth-supporting periodontium, the alveolar bone, the root cementum, and the periodontal ligament. This progressive destruction occurs through the action of bacteria that activate pro-inf... | null |
CRD420251026641 | The objective of this systematic review and meta-analysis is to evaluate and quantify the effectiveness of exercise interventions in reducing the risk of falls among elderly individuals. Specifically, the review aims to identify which types, durations, and intensities of exercise programs are most beneficial for fall p... | Will include adults aged over 60 years with fall risk, Balance exercises; Stretching Exercises; Aerobic Exercise This review will include studies that investigate structured exercise or physical activity interventions designed to reduce the risk of falls among older adults (typically aged 60 years and above). To be eli... | Will excluded studies in which when participants were selected for a specific neurodegenerative disease or any other characteristic that greatly affected the risk of falling but was not correctable by exercise (such as severe visual impairment). This review will include studies that evaluate structured exercise interve... |
CRD420250650655 | In reproductive-aged women diagnosed with polycystic ovary syndrome (PCOS), based on currently reported randomized controlled trials, do lifestyle modification improve clinical reproductive outcomes? | Polycystic ovary syndrome (PCOS) represents one of the most prevalent endocrine disorders affecting women of reproductive age, with a global prevalence ranging from 6% to 26%. This complex condition is defined by three key features: hyperandrogenemia, ovulatory dysfunction, and polycystic ovarian morphology. Despite af... | null |
CRD420250656554 | This review aims to investigate the effectiveness of rhythmic auditory stimulation on gait rehabilitation in patients with Parkinson's disease by analyzing existing experiments, including changes in gait parameters and walking rhythm before and after the experiments, in order to discover the improvement effect of this ... | Parkinson's Disease The patients are generally elderly patients with Parkinson's disease, with an average age range of 60 to 70 years old. They have been diagnosed and have an uneven disease course. They can walk independently and do not have visual impairments or other musculoskeletal, cardiovascular or neurological d... | null |
CRD420250616655 | What is the evidence regarding the effect of phyiotherapy scoliosis-specific exercices on pain, functional disability, quality of life and Cobb angle in adults? | Scoliosis Deformity Of Spine; Physiotherapeutic scoliosis-specific exercises ; Pain; Quality of Life; Disability Scoliosis, from the Greek (skolios) means sinuous, is therefore defined as a frontal misalignment of the spine, which can be structural (usually caused by differences in the size of the lower limbs) or funct... | Studies that treated patients with scoliosis due to tumors, trauma, neuromuscular diseases, congenital causes, and a history of surgery for scoliosis treatment are excluded. Studies with patients who underwent post-surgical treatment will also be excluded. Exclusion criteria will be studies that treat patients with sco... |
CRD42024551103 | The review question for this meta-analysis is: "How effective is Kinesio Taping (KT) in managing Myofascial Pain Syndrome (MPS) in terms of pain intensity and Pressure Pain Threshold (PPT) among human participants diagnosed with MPS, as compared to control groups receiving no intervention, placebo, or sham taping?" Thi... | The condition being studied in this systematic review is Myofascial Pain Syndrome (MPS), a prevalent musculoskeletal disorder characterized by the presence of myofascial trigger points (MTrPs) within skeletal muscle fibers. These hyperirritable and painful points are associated with localized and referred pain, muscle ... | null |
CRD420250649952 | In preclinical animal models of osteoporosis, what are the effects of food-derived extracellular vesicles (EVs) compared to placebo/no intervention on bone mineral density (BMD), bone microarchitecture parameters (BV/TV, Tb.Th, Tb.Sp, Tb.N), and serum bone turnover markers (OPG, PINP, TRACP 5b, β-CTX)? | Osteoporosis. Bone mineral density. Studies involving osteoporosis animal models, with no restrictions on modeling methods or animal species Research using any food-derived EVs as an intervention Any study should include a control group (such as placebo, PBS or saline). | Studies not involving animal models of osteoporosis Studies using EVs from non-food sources for the treatment of osteoporosis Without a control group (such as placebo, PBS or saline). |
CRD420251027005 | The general aim of this review is to conduct a comprehensive analysis of the existing scientific evidence regarding the treatment of chronic Chagas cardiomyopathy (CCC). The specific objectives are: To evaluate the effect of pharmacological therapy with beta-blockers, compared to placebo, on cardiac function, hospital ... | Adult patients (aged 18 years or over) with a confirmed diagnosis of chronic Chagas cardiomyopathy (CCC) undergoing clinical, pharmacological treatment involving devices, or non-pharmacological treatment for CCC, when compared with a control group (placebo, standard treatment, or other active treatment), without any li... | null |
CRD42024547684 | Coronary Artery Disease (CAD) presents a formidable challenge to global health. Despite advancements in treatments through lipid-lowering and antithrombotic medications, healthcare systems are burdened by CAD's persistently high prevalence. The development of novel drug targets for CAD remains an imperative need. | Our manuscript centers on Coronary Artery Disease (CAD), a disease linked to a global health crisis characterized by the build-up of atherosclerotic plaque in the coronary arteries. This accumulation obstructs blood flow and elevates the risk of cardiovascular complications such as myocardial infarction, which can lead... | null |
CRD42024537963 | The effect of 4DCT derived images using functional lung avoidance technique and traditional volumetric dose restriction on the prevention and treatment of radioactive lung injury in lung cancer. | Current advances in radiotherapy computer algorithms and therapeutic techniques such as 4DCT and nuclear functional imaging are used in radiotherapy planning. 4DCT relative to nuclear element functional imaging has the characteristics of clinical accessibility, low radiation and low cost. Treatment of lung cancer Avoid... | null |
CRD42023399263 | In this review, we aim to address the following questions:
1- What are different types of cardiomyocyte regeneration therapies and how are they beneficial in patients with heart diseases? How much effective are they in improving LVEF and reducing scar/infarct size?
2- What are the benefits, risks and limitations of the... | The main objective of this review is to study the effects of different types of cardiomyocyte regeneration therapies in post-MI patients with Heart failure. This review also aims to throw a light on the limitations and effectiveness of cardiomyocyte regeneration therapies with special focus on left ventricular ejection... | null |
CRD420250655187 | "How does professional self-doubt in psychotherapists impact clinical practice, therapist well-being, and therapy outcomes?" | Professional self-doubt refers to uncertainty or lack of confidence in one's own professional abilities, knowledge, or decision-making, often despite objective competence. It can manifest as imposter syndrome, excessive self-criticism, or fear of making mistakes, potentially impacting performance, well-being, and profe... | null |
CRD42020189633 | For patients on vancomycin, does AUC-based monitoring compared to trough-based monitoring result in differences in efficacy or toxicity? | Patients being treated for an infection with vancomycin.
This study will look at all infections as well as all types of causative organisms | null |
CRD420250584443 | General Research question:What insights do current computational models provide into the wound healing process, specifically,the immune response and outcome at the local and systemic level, and respective complications arisingfrom burn injury in skin?Sub-research questions:What are the computational models currently us... | Burn; Clinical Support; Computer delivered intervention; Immune response; Burn Of Skin; Wound Healing In this systematic review we cover burn injury wound healing effects on the local and systemic responsein all stages Hemostasis, Inflammatory, Proliferative and Remodeling(scar formation) We included papers that specif... | null |
CRD420250655171 | research aim： This study intends to accurately quantify the incidence of CIM through systematic analysis. The results of the study will provide a basis for risk stratification, personalized treatment adjustment, and targeted interventions to reduce complications and optimize treatment outcomes. | Breast Cancer; Chemotherapy Inclusion criteria ① P（Population）target population : breast cancer diagnosed by pathological tissue, age ≥ 18 years old ;② E（Exposure）exposure factors : factors that can affect the occurrence of bone marrow suppression in patients and exposure factors are clearly defined ;③ C（Control）contro... | null |
CRD420250627682 | 1. What are the recently discovered major putative phytochemicals with antiaging properties? 2. Can sirtuins play a role in the activities of such phytochemicals through a defined mechanistic pathway? | Oxidative stress damage and age-related diseases: These sorts of conditions affect every individual that are predisposed and contribute significantly to the decline in the expected quality of life The search was left open without restriction concerning the use of animal models. Thus, the design considered all the model... | Animal models other than aging and oxidative stress; human models, ex vivo or in silico models are excluded Unspecified comparators or experimental conditions different from that of interventions. |
CRD42024516507 | A Study on Therapeutic Impact and Safety Profile of Hypoxia-Inducible Factor Stabilizers for Kidney Disease-Related Anemia in Patients undergoing dialysis and Patients who are not receiving dialysis. | The systematic review focuses on kidney disease-related anemia in patients undergoing dialysis and those not receiving dialysis. The study examines the therapeutic impact and safety profile of Hypoxia-Inducible Factor (HIF) stabilizers, specifically exploring their effectiveness and safety in the treatment of anemia as... | null |
CRD42022329520 | How do pharmacological treatments for Gambling Disorder compare with placebo and with each other in terms of efficacy and tolerability? | Gambling Disorder/Pathological Gambling/Disordered Gambling | null |
CRD42020211834 | The aim of this meta-analysis of randomized controlled trials is to evaluate the effiicacy and safety of acupuncture therapy for autism spectrum disorder. | children autism spectrum disorder（ASD）is a psychological development disorder characterized by deficities in social communication and social interacation, and restricted, repetitive patterns of behavior, interests or activities.it usually affect children in thier 1-3years old with special symptoms, and has been the mai... | null |
CRD42022335448 | What are the fall prevention interventions in low- and middle-income countries for reducing the number of falls in community-dwelling older adults?Do fall prevention interventions in low- and middle-income countries have an effect on the number of falls, risk of falls, balance, falls related fractures and hospitalizati... | Fall prevention interventions Community Dwelling adults aged 60+ years in low- and middle-income countries will be the population for this review. A variety of therapeutic approaches to minimize and prevent falls are aimed to be identified. Effectiveness of single, multiple and multifactorial interventions including ex... | null |
CRD420250653512 | What are the factors impacting disclosure and detection of harmful sexual behaviours between siblings at an individual, family and contextual level?What individual, family, and contextual support mechanisms or interventions facilitate the disclosure and detection of harmful sexual behaviours between siblings, and how a... | Victim Of Child Sexual Abuse; Child Sex Abuse; Discussion Harmful sexual behaviour between siblings (HSB-S) is recognised as a common type of family violence globally, possibly as harmful as other forms of familial abuse (Meyers, 2014; Yates, 2020). Despite increasing awareness of HSB-S, it remains poorly understood wi... | Studies focusing exclusively on adults (18 years and older) as victims or perpetrators. Cases involving non-sibling perpetrators (e.g., parents, other relatives, peers, strangers) Studies that do not differentiate sibling sexual abuse from other types of child sexual abuse Research focused solely on therapy models, cou... |
CRD42024550429 | The current research has demonstrated that resistance training effectively enhances muscle strength and improves muscle function. However, with advancing age, both muscle strength and quality significantly decline, leading to the emergence of the concept of sarcopenia in recent years. A considerable number of clinical ... | Sarcopenia is a progressive and systemic skeletal muscle disorder associated with aging, posing a significant threat to the health and quality of life of older adults and increasing their risk of falls and even mortality. With the aging of the population becoming increasingly severe, it is expected that the prevalence ... | null |
CRD420250654721 | In the systematic review, we shall assess the efficacy of therapeutic plasma exchange (TPE) in improving survival and as a bridge to liver transplantation (LT) in acute liver failure (ALF). Secondary, we shall assess the safety of TPE by comparing adverse events to standard medical therapy (SMT). The findings on the ef... | Acute liver failure (ALF) is a rare and critical syndrome mainly driven by hyperammonemia and damage-associated molecular patterns (DAMPs). Therapeutic plasma exchange (TPE) intend to clear these from the systemic circulation, potentially supporting liver function during native recovery or providing more time until liv... | Patients with underlying liver abnormality Other extracorporeal liver support devices both artificial (e.g. MARS, Prometheus) or bioartificial (e.g. HepatAssist, BAL) |
CRD42024587857 | What are the reported health outcomes, adverse events and patient satisfaction related to the use of botulinum toxin (botox) for various physical health conditions across different specialties? | Botulinum toxin (commonly known as Botox) is gaining recognition as a potential treatment for various physical health conditions. Research has explored Botox as a therapeutic option for conditions such as chronic migraines, muscle spasticity, cervical dystonia, hyperhidrosis, sialorrhea, anal fissures, GI motility diso... | null |
CRD42023368388 | What is the effect of tDCS on pain in patients with radiculopathy? | The condition being studied is radiculopathy. Radiculopathy is defined as spinal nerve root dysfunction resulting in dermatomal pain and paresthesias, myotomal weakness, and/or impaired deep tendon reflexes. Radicular pain, also known as radiculopathy, is frequently present along with axial spine pain. Neck and low bac... | null |
CRD420251009413 | In patients with diabetic peripheral neuropathy, how effective are physical therapy interventions compared to pharmacological treatments or usual care in reducing neuropathic pain and improving quality of life? | Adults diagnosed with diabetic peripheral neuropathy (DPN), experiencing neuropathic pain as a result of type 1 or type 2 diabetes. Studies including both male and female participants, regardless of duration of diabetes or severity of neuropathy, will be considered. Electrotherapy; Acupuncture; Electroacupuncture; Refl... | systematic reviews and meta-analysis |
CRD42025638659 | “The primary aim of this systematic review and meta-analysis is to evaluate the clinical efficacy of acupuncture in treating neuropathic pain in adults. Specific research questions include:
What is the effect of acupuncture on neuropathic pain relief compared to placebo or standard treatments?
How does acupuncture comp... | This review focuses on neuropathic pain, a chronic condition caused by nerve injury or dysfunction. It is commonly observed in conditions such as diabetic neuropathy and postherpetic neuralgia, and is associated with persistent pain, sensory disturbances, and significant impairment of daily activities. The review inves... | null |
CRD42024551594 | Do new therapies for IgA Nephropathy reduce proteinuria and protect kidney function? Which is the best among them and for what type of patients? | IgA nephropathy, or Berger's disease, is a kidney disorder characterized by the deposition of immunoglobulin A (IgA) in the glomeruli, causing inflammation and renal dysfunction. It is the most common primary glomerulonephritis globally, presenting variably from asymptomatic hematuria to rapidly progressive glomerulone... | null |
CRD42024611113 | Using the method of network meta-analysis based on Bayesian models, this study systematically evaluates the relevant research on the treatment of acute ischemic stroke with Yiqi Fumai herbal injections of traditional Chinese medicines. It provides probabilistic rankings of various Yiqi Fumai herbal injections of tradit... | The Treatment of Acute Ischemic Stroke with Yiqi Fumai herbal injections of Traditional Chinese Medicines | null |
CRD42024528071 | To compare the outcomes of different treatment modalities in Keratoacanthoma. | Keratoacanthoma, a unique skin tumor characterized by rapid growth and potential for spontaneous regression, often presents diagnostic and therapeutic challenges due to its resemblance to squamous cell carcinoma. Despite various available treatments, ranging from surgical excision to non-invasive options like cryothera... | null |
CRD420250654572 | What is the clinical efficacy of sweet orange (Citrus sinensis) aromatherapy in managing pain, fatigue, anxiety, depression, and sleep quality across various patient populations? | Post viral fatigue syndrome; Dialysis related complication; Pain Intensity; Gastrointestinal inflammation pediatric with procedural anxiety, patient dialysis-related somatic distress, and patient post-viral fatigue syndrome (post-COVID-19) Inhalation Therapy Management; Body Massage PICO tags selected: Usual Care; Plac... | null |
CRD42024626837 | P:Hashimoto's Thyroiditis
I:Traditional Chinese Medicine Physical Therapies(Acupuncture, Moxibustion, Tuina, and Combined Interventions)
C:Conventional medicine
O:Primary Outcome:TSH、FT3、FT4、TPOAb、TgAb
S:RCT
Questions: This study intends to use a network meta-analysis method to compare the therapeutic effects of acupun... | Hashimoto's thyroiditis (HT) is often accompanied by thyroid dysfunction and systemic symptoms, seriously affecting quality of life. The current mainstream treatment method is levothyroxine replacement therapy, but it is difficult to comprehensively improve immune function and alleviate chronic symptoms. Therefore, exp... | null |
CRD42023478377 | To ascertain the level of evidence regarding anesthesia related clinical interventions in adults undergoing urgent/emergent craniotomy/craniectomy under general anesthesia and to assess the available interventions and any related outcomes.
Definition of emergency craniotomy/craniectomy: Craniotomy/craniectomy performed... | Craniotomy/craniectomy performed in a patient with clinical, radiographic or intracranial pressure monitoring-based diagnosis of intracranial hypertension and or herniation | null |
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