Study_ID string | Objectives string | Included string | Excluded string |
|---|---|---|---|
CRD42025636193 | Population: Patients diagnosed with gastrointestinal cancer .
Intervention/Exposure: Exploration of factors (demographic, clinical, psychosocial, geographic, cultural).
Comparison: NA.
Outcomes: Suicidal ideation, mental health outcomes.
Study design: observational studies | Gastrointestinal (GI) cancers are common and often result in significant psychological distress. Patients with GI cancers, particularly those undergoing treatment, are at higher risk for mental health issues, including suicidal ideation (SI). Factors such as disease stage, treatment type, psychological strain, and demo... | null |
CRD420251024259 | The current systematic review aims to draw together evidence on the experience of community mental health staff providing therapeutic support to people who self-harm (SH). | Community mental health staff e.g., counsellors, psychotherapists, community mental health nurses Support Providing therapeutic support to adults who self-harm All qualitative research designs. Mixed designs where qualitative findings can be extracted | Inpatient/ambulance staff, medical community staff e.g., GPs, prison staff Supporting individuals with another difficulty/ particular diagnosis e.g., suicide attempt, BPD or specific groups e.g., children, older adults Non-qualitative research designs i.e., quantitative only or mixed method designs where qualitative fi... |
CRD420251013918 | To compare the effects of low-intensity exercise with other exercise levels in post-stroke patients using a meta-analysis approach | Patients aged 18 years, diagnosed with stroke within the past 1 month, and able to walk at least 10 meters Low-intensity exercise PICO tags selected: Moderate-to-vigorous intensity physical activity | null |
CRD42022345996 | Traditional Chinese Medicine (TCM) constitution conditioning offers a vital intervention to prevent the development of functional constipation.This review will explore the distribution of TCM constitution types in functional constipation and provide information for preventing and treating functional constipation by mod... | Functional constipation is a functional bowel disease that excludes organic causes. The main clinical manifestations of functional constipation are reduced stool frequency (usually three times a week), dry stool or persistent difficulty, and frequent or incomplete excretion. Long duration, easy recurrence, and poor eff... | null |
CRD42021276301 | P：Patients with endometriosis；I：nine kinds of Traditional Chinese Medicine Constitution；C：People without endometriosis；O：the Association between endometriosis and Traditional Chinese Medicine Constitution；S：Case control study or Cross sectional study | Endometriosis (EMS) is an endocrine disease characterized by pain (including chronic pelvic pain, secondary dysmenorrhea, sexual intercourse pain, etc.), infertility, chronic pelvic adhesion, menstrual disorder, non uterine bleeding, nodules and masses. The incidence rate of endometriosis in the growth period is 10%, t... | null |
CRD42024471231 | This review will aim to inform the development of a vulnerability assessment tool and selection of evaluation metrics. We will consider the following research questions:
1. What vulnerability factors affect health-related outcomes in Adults With Intellectual Disability (AWID)?
• Which matters most / least?
• What aspec... | The biological, psychological, social or crosscutting biopsychosocial vulnerability factors affecting health and wellbeing outcomes on AWIDs.
Health Outcomes: In Donabedian (1996)’s definition, it is defined as “‘changes in patients’ health and welfare resulting from medical care or from a lack of care” [1]. We define ... | null |
CRD42022376117 | The main objective of this review is to develop a research-based clinical guideline for outpatient psychotherapeutic treatment for PTSD and C-PTSD, in order to ensure that the best possible treatments are implemented in clinical practice. The systematic reviews informing the clinical guideline, will aim to answer five ... | Psychotherapeutic treatment of post-traumatic stress disorder (PTSD) with/without comorbid personality disorders, depressive disorders, and dissociative disorders, as well as complex post-traumatic stress disorder (C-PTSD). | null |
CRD42020183998 | What is the effectiveness of telephone and videoconferencing therapy on mental health outcomes, compared with traditional face-to-face therapy, for the treatment of adults with mental health disorders? | Individuals who are diagnosed with mental disorders such as major depressive disorder, generalized anxiety disorder, and substance use disorder. | null |
CRD42023400047 | 1. What are the interventions tailored to bereaved Black Americans.
2. Are there special/cultural considerations regarding bereaved Black Americans?
3. What are the health-seeking behaviors of bereaved Black Americans? | Psychological, behavioral, and sociocultural factors influence the grieving process. Prior research focused on mitigating grief has largely been void of the sociocultural factors or contexts that substantially affect the efficacy of grief therapy among individuals from diverse sociocultural backgrounds. This review att... | null |
CRD420250639163 | 1. What conversational agent-integrated interventions have been developed and implemented to reduce loneliness and social isolation? What specific technologies or conversational agents were utilized in these interventions?2. How can these conversational agent-integrated interventions be categorized based on their funct... | Loneliness; Social Isolation ; Mental disorder Loneliness, Social Isolation The review will include studies targeting on all potential types of participants or populations, irrespective of their health status, socio-demographics, and other characteristics. Digital intervention Eligible studies should introduce or evalu... | null |
CRD420250628251 | How do younger women with breast cancer experience fear of cancer recurrence? What factors may exacerbate fear of recurrence?What may help with fear of recurrence?How do women cope with fear of recurrence? | Breast cancer is the most common cancer among women in the UK (15% of cases) (Cancer Research UK, 2024). While older individuals, particularly women over the age of 90, have the highest incidence of breast cancer (Cancer Research UK, 2024); younger women have disproportionately worse outcomes, higher risks of recurrenc... | null |
CRD42022320589 | An objective of this systematic review is to synthesize the best available evidence concerning the preventive effect of iCBT on employees. Review questions are: 1) In comparison to controls, what is the preventive effect of iCBTs delivered in the workplace to improve psychological outcomes (i.e., stress, anxiety, depre... | Psychological outcomes and work engagement among employees in the workplace This review will admit studies that include non-healthcare workers such as office workers, military, and teachers regardless of socio-cultural background. Studies recruiting participants who have diagnoses of mental disorders or any health prob... | null |
CRD42024560728 | What are the healthcare experiences of autistic sexual minorities | Not applicable | null |
CRD42024578199 | The present review will aim to explore service users' experiences of accessing and using mental health crisis helplines:How do service users experience accessing and using mental health crisis helplines, and what factors are perceived to be helpful or unhelpful in this process? | Mental Health Crisis Resolution Mental Health Crisis Helpline Services. Individuals who have contacted a mental health crisis helpline service (i.e. crisis line, suicide prevention line). Inclusion Criteria- Adults (>18 years old)- 'Callers' who have accessed the intervention (as specified below) Exclusion Criteria- Ch... | null |
CRD42024527466 | What is the diagnostic profile of different combinations of dual disorders (substance use and another psychiatric disorder) in the clinical setting? | Dual Diagnosis (substance use disorder comorbid with another psychiatric disorder). Dual diagnosis or dual disorders is a common occurrence in the clinical setting and may alter the course and prognosis. Substance use disorders are expected to be more common in people with mental health conditions than expected by chan... | null |
CRD420250650845 | The central aim of this qualitative systematic review is to explore and synthesize the various conceptualizations of mental health literacy (MHL) by using content analysis. In doing so, this review aims to identify the core dimensions of MHL in differentiation to predictors and outcomes of MHL and to achieve a more pre... | MHL is a concept that was first introduced by Jorm and colleagues in 1997 and defined as the knowledge and beliefs regarding mental disorders that assist in their identification, treatment, and/or prevention. Since then, the concept of MHL has evolved, with particularly strong momentum over the last five years, expandi... | null |
CRD42024610941 | 1) To what extent do school-based physical activity, physical literacy, and executive function interventions influence academic performance and health outcomes in primary school-aged children?
2) Within existing research, what are the main gaps in school-based physical activity, physical literacy, and executive functio... | Physical activity, physical literacy, executive function, and academic attainment in primary school-aged children. | null |
CRD42024505603 | How effective are Internet- and mobile-based interventions in the treatment of Tic disorders among children, adolescents, and adults? | The systematic review focuses on Tic disorders, a spectrum of neuropsychiatric conditions characterized by sudden, rapid, recurrent, non-rhythmic motor movements or vocalizations. Commonly manifesting in childhood, these disorders include transient and chronic forms, such as Tourette Syndrome. Tics can vary in severity... | null |
CRD420251016170 | 1. What interventions have been implemented to improve the mental health of nurses, and how effective have they been? | Population: Registered nurses, nursing students, and nurse practitioners working in any healthcare setting (e.g., hospitals, clinics, long-term care facilities). Mental Health Care Education; Wellness Promotion; Physical activity programme; Lifestyle education Mental Health Interventions: Psychological counseling, str... | Non-Nurses: Studies focusing on healthcare workers other than nurses (e.g., doctors, allied health professionals). Interventions not related to improving mental health, physical health, well-being, or lifestyle behaviors, such as administrative or management-focused interventions. Case studies, case series, editorials... |
CRD420251021563 | The primary objective of this systematic review is to evaluate the role of technology in enhancing art-based therapy for individuals with Autism Spectrum Disorder (ASD). Specifically, our the review seeks to address the following questions: | All participants should have a confirmed diagnosis of Autism Spectrum Disorder, adhering to established diagnostic criteria such as the DSM-5 or ICD-10 .Participants must be aged 3 to 30 years. Art Therapy; Robotic-assisted training PICO tags selected: Skills Training; Social Skills Training; Music Therapy | Non-Art-Based Interventions, Lack of Technological Component, Age Outside Specified Range, Insufficient Outcome Data, Comorbid Conditions (Studies where participants have significant comorbid conditions that may affect the outcomes (e.g., severe intellectual disability)) may be excluded. |
CRD420250644719 | What are the existing stimuli and induction methods used in experimental anxiety detection studies, how do these methods compare in terms of effectiveness and reliability based on physiological and psychological outcome measures | Anxiety; Mental disorder Anxiety is a natural response to stress, characterized by feelings of worry, fear, or unease. It can range from mild to severe and may include physical symptoms like a rapid heartbeat, sweating, or restlessness. While occasional anxiety is normal, persistent or excessive anxiety may indicate an... | studies involving non-human subjects, as well as those that do not assess anxiety using ECG or PPG |
CRD420250605187 | Are interventions and services effective in preventing cardiovascular diseases for people prescribed antipsychotics? | Cardiovascular Event Risk Cardiovascular disease (CVD) Adults with exposure to antipsychotics or adults diagnosed with severe mental illness will be included. Antipsychotic drugs informed by the British National Formulary and consultations with GPs and psychiatrists, including Chlorpromazine; Chloractil; Dozine;; Larga... | Studies that included mixed populations will be excluded unless separate results for people taking antipsychotics or those with SMI can be identified or obtained from the trial investigators. Interventions not designed for CVD prevention will be excluded. |
CRD420250652020 | What are the approaches to prevent Suicidality and co-morbid psychological problems among adolescents which can be implemented in educational educational institutes? | Suicide; Suicidal Behavior; Suicidal; Suicidal Thoughts; Suicide Prevention; Suicidal Intent; Suicide Attempt; Adolescence My purpose behind doing a systematic review is to identify all possible, latest approches to treat suicidality along with other psychological problems which result in suicidality i.e depression, st... | Students who don't fall in the age criteria of adolescence. 1. Interventions which are not randomized. |
CRD42025565935 | What experiences do children and those supporting children, report in relation to school transitions during the early stages of adolescence? | 2. Experiences and perspectives of children aged between the 11-15 years and caregivers during transition from primary – secondary settings | null |
CRD42023455062 | 1) What was the prevalence of affective mental health problems during the COVID-19 pandemic among PLHIV, especially in LMICs?
2) What were the correlates of common mental health conditions during the COVID-19 pandemic? | People living with HIV (PLHIV) are disproportionately affected by mental health conditions compared to the general population. This was further compounded by the COVID-19 pandemic with the associated disruption in care and support services along with greater risk of complications and mortality in people with pre-existi... | null |
CRD420250650895 | The study aim to assess the frequency of recommendation of physical activity by mental health professionals. | Exercise prescription rate Healthcare professionals physiotherapists, psychiatrists, nurses, occupational therapists, psychologists, among others Does not apply | Does not apply Does not apply |
CRD42021259246 | 1. What behaviour change techniques (BCTs) as defined by The Behaviour Change Techniques Taxonomy (BCTTv1, Michie et al., 2013) are used in digital health interventions for midlife women?
2. What behaviours (i.e. diet, exercise, mental health) are targeted in digital health interventions?
3. What modes of delivery (i.e... | We plan to review health interventions with midlife women (age 40 – 65 years) that aim to modify any health behaviour. Health behaviours may include diet, exercise, mental health, and symptoms associated with menopause (i.e. hot flushes, low mood, anxiety, tiredness, poor concentration, poor sleep, change in weight/bod... | null |
CRD420250649955 | Determining the relationship between childhood sexual abuse and eating disorders, body dissatisfaction and disordered eating in children and adolescents: a systematic review.Primary Aim: The intention of this paper is to conduct a systematic review, analysing the current data to determine the relationship between child... | Eating disorders (including anorexia, bulimia nervosa, binge eating disorder, avoidant restrictive food intake disorder, eating disorder not otherwise specified and unspecified eating disorder) and disordered eating and weight concern. Individuals with eating disorders (children and adults), disordered eating and body ... | null |
CRD420250645117 | 1. What psychosocial factors contributed to decline in mental health during the COVID-19 pandemic? | Mental disorder; Depression; Anxiety Healthcare Workers who are regulated and directly involved in patient care. Healthcare workers involved in patient care during the period of the COVID-19 pandemic | null |
CRD42024586018 | 1. What is the prevalence of Avoidant/Restrictive Food Intake Disorder (ARFID) in children and adolescents (<18 years)?
2. What is the prevalence of Autism Spectrum Disorder (ASD) among children and adolescents with ARFID?
3. What is the prevalence of medical and mental comorbidities in children and adolescents with AR... | Avoidant/Restrictive Food Intake Disorder (ARFID) is an eating disorder characterized by a persistent pattern of consuming a limited variety of foods, coupled with an aversion to certain sensory aspects of food, leading to significant nutritional deficiencies, weight loss, or impairment in psychosocial functioning. Unl... | null |
CRD42023452292 | Review Question:
What is the effectiveness of Neurolinguistic Programming (NLP) in improving health outcomes and well-being in patients with various health conditions?
P - Population: Patients with various health conditions (e.g., chronic pain, anxiety disorders, depression, etc.)
I - Intervention: Neurolinguistic Prog... | The systematic review focuses on the use of Neurolinguistic Programming (NLP) in various healthcare domains to improve health outcomes and well-being in patients with different health conditions. NLP is a psychological approach that aims to understand the relationship between language, thought patterns, and behavior. I... | null |
CRD420250653581 | - What are the desired outcomes to support health promotion in chiropractic care related to behaviour change skills? | Chiropractic Visit; Behaviour change technique; Health Promotion; Musculoskeletal Pain 1. Chiropractic care setting 2. MSK 3. Health promotion 4. Behaviour change Chiropractors (to be registered with regulator) Behaviour change skills/techniques and/or health promotion strategies/activity | null |
CRD42018098747 | (1) To investigate the prevalence rates of the Hikikomori syndrome (HS) of prolonged social withdrawal in the general population (the general population will include individuals recruited from the community or students/undergraduates).
(2) To investigate the prevalence rates of the HS in treatment-seeking clinical samp... | In the last two decades, the “Hikikomori” syndrome (HS) has been conceptualised as a psychosociological condition characterized by prolonged and severe social withdrawal for a period of at least 6 months (Kaneko, 2006; Saito, 1998; Watts, 2002). This condition was first reported and studied in Japanese society/culture ... | null |
CRD42023440564 | What are service user experiences on crisis home treatment teams? | CHTTs are short-term, intensive at-home treatments aimed to reduce hospital admissions and provides support to individuals returning home after an acute hospital admission (Johnson & Thornicroft, 2008). CHTTs can help service users develop coping strategies, and promotes family involvement and social support during a c... | null |
CRD420250656284 | How effectively do physical therapy interventions improve muscle strength and functional outcomes in patients with ICU-acquired weakness (ICU-AW)? | Intensive care unit acquired weakness; Physical therapy exercises; Muscle Strength ICU-acquired weakness (ICU-AW) is a common complication in critically ill patients, characterized by profound muscle wasting and impaired physical function. It is associated with prolonged mechanical ventilation, immobility, and systemic... | Exclusion criteria:1.absence of coexistent neurological or orthopaedic illness.（e.g. Guillain Barre Syndrome,stroke）2.unable to participate in physical therapy (e.g. unstable hemodynamics). |
CRD420250620296 | How does economic inequality influence the mental health outcomes of children and adolescents compared to those living in more economically equal environments?What specific mental health disorders are particularly affected by economic inequality among children and adolescents? | Economic Problem; Mental State Finding; Child Health Promotion This meta-analysis examines economic inequality and its impact on mental health in children and adolescents. Economic inequality refers to the disparities in income and wealth within a society, which can limit access to resources and support. This inequalit... | Exclusion Criteria: 1. Lack of Comparative Analysis: Studies that fail to examine mental health outcomes across varying levels of economic inequality (e.g., no subgroup comparisons, regression models, or correlation analyses). 2. Age: Research focused on adults or other age groups. 3. Irrelevant Contexts: Studies not e... |
CRD42023456623 | For whom and in what circumstances does co-production work in youth mental health services?
Subquestions:
- What are the important contextual factors in understanding co-production in youth mental health services?
- What mechanisms explain the impact of co-production in youth mental health services?
- What are the outc... | Co-production of youth mental health services | null |
CRD42024530897 | Population: Individuals at risk of suicide or with a history of suicidal behavior.
Intervention: Artificial Intelligence (AI) algorithms for predicting suicide risk.
Comparison: Conventional methods or other risk assessment tools.
Outcome: Accuracy of AI in predicting suicide risk or identifying individuals at risk of ... | The systematic review focuses on the use of Artificial Intelligence (AI) algorithms for predicting suicide risk among individuals. It examines the application of AI in identifying those at risk of suicide or with a history of suicidal behavior. | null |
CRD42022342605 | To review the literature on 12-step facilitation AND mutual-help group, focusing on, but not limited to: (i) mental disorders other than alcoholism and (ii) qualitative studies. | Inclusion criteria:
• "12-step group" OR "12-step program" OR "12-step facilitation" OR "12-step approach" NOT alcohol NOT alcoholism NOT alcoholic NOT alcoholics
• "12-step group" OR "12-step program" OR "12-step facilitation" OR "12-step approach" AND qualitative
• "Narcotics Anonymous" NOT alcohol NOT alcoholic NOT ... | null |
CRD42024604765 | Q1: What is the combined effectiveness of neurofeedback and complementary treatments in reducing mental disorder outcomes in adults?
Q2: How does standalone neurofeedback therapy compare to an integrated approach that combines neurofeedback with complementary therapies in treating mental disorders? | Emotion regulation. Mental disorders. | null |
CRD42024611094 | Research Question: What is the pooled association between nomophobia and its related factors - antecedents and consequences.
The following are detailed objectives:
1. To estimate the pooled association between antecedent factors and nomophobia.
2. To estimate the pooled association between nomophobia and consequences.
... | Nomophobia, a term that describes the anxiety or discomfort experienced when one is without a mobile phone, has become increasingly prevalent in recent years as mobile technology has become a fixture in daily life. This phenomenon has raised significant concerns regarding its potential effects on mental health and well... | null |
CRD42021231112 | What policies, interventions and prevention strategies exist for preventing alcohol-related suicide? Which of these interventions are effective in preventing suicide and suicide attempts? | Suicide death, attempted suicide, alcohol use (including alcohol use disorder) | null |
CRD420250655575 | To identify and evaluate the measures that are used to ascertain Positive Childhood Experiences in youth populations. | We will review studies that focus on the domain of mental health and wellbeing. Namely, we are interested in mental health outcomes such as internalising (e.g., anxiety, depression) and externalising (e.g., conduct issues) outcomes in addition to wellbeing (e.g., authenticity, happiness, life satisfaction). Hence, this... | Studies that only measure ACEs but not PCEs will be excluded from this review. |
CRD42024620776 | Primary Review Question:
What are the mechanisms of action of Tai Chi in improving cardiovascular health outcomes compared to aerobic exercise?
Secondary Specific Questions:
1. Does Tai Chi reduce cardiovascular risk markers (e.g., blood pressure, lipid profiles, inflammatory markers) as effectively as aerobic exercise... | This systematic review focuses on cardiovascular diseases (CVD), which are the leading cause of mortality globally, including conditions such as hypertension, coronary artery disease, heart failure, and stroke. It specifically examines the effects of Tai Chi, a mind-body exercise, on cardiovascular health outcomes, inc... | null |
CRD42024544252 | 1. Synthesising the lived experiences and perceptions of youth with ADHD.
Inclusive of, but not limited to, their experiences and perceptions of socialisation, education, self-care, employment, leisure, mental health and wellbeing. | Attention Deficit-Hyperactivity Disorder (ADHD) in youth.
The World Health Organisation (WHO) define ADHD through it’s 3 subtypes: “inattention – not being able to stay focused, hyperactivity – excess movement that is not appropriate to the setting or excessive fidgeting, tapping or talking, impulsivity – acting hastil... | null |
CRD42021244278 | The objective of this study is to describe the impact of long-term highly active antiretroviral therapy (HAART) use on health-related quality of life (HRQoL) among people with HIV/AIDS (PLWHA).
For this study, our research question is:
- What effects do the prolong use of HAART have on the HRQoL of PLWHA? | The human immunodeficiency virus (HIV) is responsible for the progressive dysregulation of the cell-mediated immune system and could ultimately lead to the acquired immunodeficiency syndrome (AIDS). The HAART is established as one of the most effective interventions for treatment of HIV/AIDS. However, research has show... | null |
CRD42025648194 | Utilizing a three-tiered meta-analytic framework, this investigation aims to provide a thorough synthesis and quantitative assessment of the relationship between childhood maltreatment and bullying victimization. | The study primarily focuses on the relationship between bullying and childhood abuse, and does not involve clinical diseases, etc. The study will conduct a global meta-analysis involving participants from countries such as China and Turkey. There is no need for retesting; only the participant information from previousl... | null |
CRD42024541437 | Overarching Review Question:Are interventions targeting family accommodation effective in reducing levels of accommodation and symptom severity in childhood anxiety and OCRDs?Sub-Questions: | Anxiety; Obsessive-compulsive Disorders And Symptoms Anxiety in Childhood. This includes any Anxiety Disorder or Obsessive-Compulsive and Related Disorder as defined in a recognised diagnostic manual (E.g. DSM-V). Anxiety disorders show high prevalence in children and young people, with one in six living with a probabl... | null |
CRD42024521415 | What are the current approaches to involving service users in mental health education and training?
What are the impact and outcomes of these approaches on healthcare education and training in mental health through service users, stakeholders, and educational materials? | Service User Involvement Approaches | null |
CRD42022342927 | The objective of this systematic review is to synthesize existing data on the impact of unwanted pregnancy or denied abortion on maternal mental health and mental health of their offspring. | Mental health | null |
CRD420250457715 | The purpose of this study was to explore the influencing factors of self-negation tendency of nursing students and nurses. | Evidence-based nursing Nursing students ( students receiving nursing professional education ) and nurses ( professionals who have registered through practice and obtained a nurse 's practice certificate ) Implant impostor phenomenon occurs (The tendency to deny one 's own ability, also known as impostor syndrome / frau... | Nurses who did not pass the practice registration and / or obtained the nurse practice certificate; nursing students and nurses who are absent from school or on vacation. |
CRD42022345093 | What is the association between victim age polymorphism and psychopathy?
AND
What is the association between victim age polymorphism and atypical sexual interest?
AND
What are the overall, sexual, and violent recidivism rates of victim age polymorphic offenders compared to child victim offenders and adult victim offend... | Polymorphic, mixed, or crossover offenders (i.e., offenders with victims in multiple age groups), mental health correlates (psychopathy; paraphilias; sexual preoccupation or hypersexuality) and recidivism | null |
CRD42024515911 | To investigate the levels of glutamatergic neurochemicals (glutamate (Glu), glutamine (Gln) and glutamate+glutamine (Glx)) across and between neurodevelopmental psychiatric conditions. | Neurodevelopmental Psychopathology | null |
CRD42023449351 | We would like to examine whether parental emotion socialization is associated with aggression, anger, and irritability in children/adolescents. Is negative parental emotion socialization, for example, associated with higher levels of aggression, anger, and irritability in children/adolescents? Is positive parental emot... | Irritability, aggression, and anger in children/adolescents | null |
CRD42024542358 | 1. What does the study demonstrate about mindfulness-based approaches and meditation programs' benefits regarding stress and anxiety among medical students?
2. To what extent do mindfulness and meditation interventions affect medical students' psychological, physical, and behavioral outcomes?
3. As students are the maj... | Stress and anxiety. Mindfulness-based interventions (MBIs) and meditation in alleviating stress and reducing anxiety. | null |
CRD42024604568 | Primary:
1. What interventions are effective in reducing proximal minority stress (e.g., internalized stigma, anticipated rejection, disclosure/concealment of identity) among SGM populations?
2. What interventions are effective in reducing distal minority stress (i.e., stigma, prejudice, and acts of violence from non-S... | Mental Health | null |
CRD42024587810 | This analysis aims to synthesize data on the prevalence of PTSD among healthcare workers from existing studies, rigorously evaluating changes in its incidence before and during the COVID-19 pandemic. By consolidating data from a series of studies, we aim to provide a comprehensive overview of the impact of a global cri... | The COVID-19 pandemic, as an unprecedented global health crisis, has had profound implications for healthcare systems and professionals worldwide. Amid the myriad challenges faced by medical personnel, the impact on emotional and mental health has emerged as a significant focal point. As frontline responders, healthcar... | null |
CRD42024600664 | Research questions were developed using the Sample, Phenomenon of Interest, Design, Evaluation and Research type (SPIDER) qualitative strategy (Cooke et al., 2012);
1.
What are the reported (Design) lived experiences (Evaluation) of parenting (Phenomenon of Interest), from the perspective (Evaluation) of autistic paren... | Neurodevelopmental condition of autism spectrum disorder in parents and children with a focus on parenting. | null |
CRD420251002666 | This meta-analysis investigates the specific roles of childhood emotional abuse and neglect in adolescent self-harm, clarifying their distinct contributions to self-harm risk. | Adolescents (under 20 years of age) Childhood Trauma Questionnaire cross-sectional study,case-control study | null |
CRD420250652858 | Research Question (PICO Model):
Population: Adolescents (aged 10 to 19 years)
Exposure: Social factors (family, peers, school environment, access to information)
Comparison: Absence or low quality of these factors
Outcome: Prevalence of psychoactive substance use | This systematic review investigates the social factors influencing the use of psychoactive substances among adolescents, focusing on both risk and protective factors within the adolescent's social environment. The study explores how family dynamics, peer relationships, school environment, and access to information cont... | null |
CRD42023406838 | 1) What is the pooled prevalence estimate of depression, anxiety, and post-traumatic stress disorder in Black post-secondary students in Canada and the U.S?
2) What are the risk and protective factors associated with these mental health difficulties in Black post-secondary students in Canada and the U.S? | Depression, Anxiety and Post-Traumatic Stress Disorder | null |
CRD42024497379 | This research has the four following interconnected objectives: (1) to explore the strength of association between racial discrimination and mental health outcomes, (2) to investigate the moderating effects of social support on the association between racial discrimination and mental health outcomes, (3) to assess how ... | This study will explore how specific forms of support, such as emotional support from family and friends or informational support from organizations, distinctly influence mental health outcomes such as depression, anxiety and suicidality in the face of racial discrimination. | null |
CRD42023429751 | The aim of this meta-review is to synthesise evidence from systematic reviews of randomised clinical trials of parenting interventions for child and adolescent mental health outcomes (i.e., symptoms, traits, or disorder level). The review will describe the effects of (1) universal, (2) targeted, and (3) indicated paren... | Mental disorder Our review will focus on mental health outcomes in the offspring of parents receiving parenting intervention. Outcomes will include symptoms, traits, and diagnoses of disorders such as conduct problems, externalising, internalising, anxiety disorders, affective disorders, personality disorders, ADHD, di... | null |
CRD42020158779 | 1) To estimate the pooled prevalence of prolonged grief disorder in Sub-Saharan Africa context.
2) To examine the relevant comorbidities and correlates of prolonged grief. | It is well known that the loss of a loved person by death is an upsetting period in one’s life, and recent empirical studies have showed that grief reactions can be severely disturbed resulting in prolonged grief disorder (PGD). Sub-Saharan Africa (SSA) has one of the highest levels of mortality globally. Better unders... | null |
CRD42023469486 | In at-risk families with children and adolescents, how does the implementation of intensive family preservation services compare to treatment as usual, alternative interventions, or a waiting list (with no care) in impacting the prevention of out-of-home placement, reduction of child maltreatment incidents, improvement... | The focus of this research is on Intensive Family Preservation Programs (IFPS), interventions designed to enhance the well-being of at-risk families with children and adolescents. IFPS is typically applied in situations where there is a significant risk of out-of-home placement for the child, instances of child maltrea... | null |
CRD42023493533 | 1. What behaviour change techniques (BCTs), as defined by The Behaviour Change Techniques Ontology (Marques et al., 2023), are used in digital health interventions for Stroke Rehabilitation?
2. What behaviours (i.e. diet, exercise, mental health, physical activity, medication adherence, lifestyle) are targeted in digit... | We plan to review health interventions focused on stroke rehabilitation. These may include interventions targeting physical recovery, cognitive enhancement, and improvements in activities of daily living. No restriction will be placed on the study size, and the behaviour change theory reported. | null |
CRD420251015607 | To systematically analyze the effectiveness and limitations of group therapy in improving mental and cognitive issues in patients with depression, both domestically and internationally, and to explore potential optimization strategies, providing references for clinical practice and research. | Children, adults and elderly with depression Group Cognitive Behavioural Therapy; Art Therapy; Mindfulness | null |
CRD42024539718 | Provide an overview of the effectiveness of structured physical activity (PA) on young people's mental health, synthesising the umbrella reviews on the topic and comparing the results with current guidelines.We chose to select umbrella reviews as they represent one of the highest levels of scientific evidence and summa... | We refer to the World Health Organization (WHO) definition of mental health as a state of mental well-being and no longer considered as the mere absence of mental disorders; it exists on a complex continuum, which is experienced differently by each individual, with varying degrees of difficulties and potentially differ... | null |
CRD42024547801 | How effective are each of three types of STAIR treatments in reducing PTSD symptoms. The three treatments are: STAIR Narrative Therapy and its extension ESTAIR, STAIR alone, and webSTAIR. | PTSD will be assessed as measured by different diagnostic systems and include DSM-5 PTSD, DSM-IV PTSD, DSM-III(R) PTSD, ICD-11 PTSD, ICD-11 CPTSD, ICD-10 PTSD. | null |
CRD42024557625 | 1. To describe the characteristics of studies that have developed or tested measures | Parental alienation refers to the actions and attitudes manifested by a child who allies strongly with one parent and rejects contact or a relationship with the other parent without legitimate justification (Bernet et al., 2022). Bernet, W., Baker, A. J. L., & Adkins II, K. L. (2022). Definitions and terminology regard... | Settings or populations where a measure of parental alienation has not been used. |
CRD42025635510 | Our systematic review and meta-analysis aim to determine whether in utero exposure to maternal corticosteroids is associated with an increased risk of anxiety and depression in childhood and adolescence. This broad question can be subdivided into specific aspects:
What is the magnitude of the risk of developing anxiety... | The review focuses on mental health outcomes, specifically anxiety and depression, following exposure to corticosteroids in utero. This involves examining neurodevelopmental outcomes in the context of prenatal pharmaceutical interventions. | null |
CRD42024613249 | What is the incidence rate of neurodegenerative diseases of elderly people in Russia? | Mild Cognitive Impairment; Dementia; Dementia Due To Alzheimer's Disease; Parkinson's Disease Degenerative disease, Cognitive Decline, Dementia, Parkinson Disease, Alzheimer Disease Adults in Russia above 50. The primary exposures to be assessed include known risk factors for dementia (where available): high cholestero... | null |
CRD42020214070 | 1. What factor structures of the International Trauma Questionnaire (ITQ) best represent the dimensionality of ICD-11 (International Classification of Diseases 11th Revision) PTSD (post-traumatic stress disorder) and CPTSD (complex post-traumatic stress disorder) constructs?
2. What are the most common groups (classes)... | The latent structure (factor analytic and mixture models) of ICD-11 PTSD and CPTSD using the International Trauma Questionnaire. | null |
CRD42021225689 | An evaluation of the effects of meditation-exclusive interventions on emotion regulation ability using the DERS. Does emotion regulation ability improve from pre- to post-meditation practice? | Emotion regulation is the activation of a goal to alter the trajectory of the current emotion experience, response and expression (Gross, 1998). Emotion dysregulation has been proposed as a factor contributing to the psychopathology of mental health disorders. Our definition of emotion regulation will follow the multi-... | null |
CRD420250645939 | How do conceptual frameworks that define dyslexia as either a neurodivergence or a cognitive impairment shape the educational experiences of individuals with dyslexia across diverse cultural and institutional contexts? | Dyslexia; Education The impact of the perceptions of dyslexia as a neurodiversity or impairment on the mental health outcomes of students with dyslexia in different educational settings across different cultures, cannot be measured through quantitative methods as this review focuses on the experiences of these individu... | Exclusion: Students with ADHD, autism or epilepsy who obtain official diagnosis for these disabilities who belong to schools and universities as they do not align with the focus of this review, which is only on students with dyslexia in different educational settings. Studies that explore parents' perspectives, and the... |
CRD42024587847 | What are the reported health outcomes, adverse events and patient satisfaction related to the use of botulinum toxin (botox) for mental health disorders? | Botulinum toxin (commonly known as Botox) is gaining recognition as a potential treatment for various mental health disorders. Research has investigated Botox as a therapeutic option for conditions such as depression, anxiety, bipolar disorder, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD),... | null |
CRD42024615866 | What are the most common causes of acute toxic exposures or presentations of patients in low-to-middle income countries?
We aim to search for acute overdoses, toxic ingestions, and any envenomation in LMICs, as well as outcome data, if reported. | We aim to study acute overdoses, ingestions, and envenomations in LMICs. The aim is to categorize, and quantify, as well as geographically depict the number of toxicology-related cases that are severe in LMICs. | null |
CRD42025621622 | To explore the impact of journalling, reflective writing, and self-monitoring on mental health outcomes/related behaviours, focusing on intervention design, implementation strategies, and underlying theoretical frameworks. | Mental health outcomes in human subjects | null |
CRD420250649645 | 1. Provide a conceptualisation of the experience of racism for racialised minority healthcare staff in the UK | The experience and the processes that perpetuate the experience of racism for staff working in healthcare in the United Kingdom will be studied. This will include narratives relating to the physical and mental health impacts of staff after experiencing racism and whilst working in racialised systems, as well as the imp... | Studies with populations of staff who do not identify as being from a racialised minority background will excluded, unless the study also incorporates the narratives of staff from racialised minority backgrounds. This study is concerned with healthcare staff working in the UK - studies located outside the UK, or concer... |
CRD42023427743 | Are positive behavioural management strategies acceptable for managing challenging behaviours in adolescent residential settings? | Identified challenging behaviours which can include self-harm, aggression, and violence are frequent in residential settings including in-patient units, residential care homes, and psychiatric intensive care units (PICU) and can lead to increases in the length of stay of a patient (Baeza et al., 2013; Dean et al., 2008... | null |
CRD42020214814 | What is currently considered best practice with regard to psychological and psychosocial interventions for adult refugees? And what do adult refugees and mental health service providers perceive to be the benefits and challenges of psychological and psychosocial interventions? | Psychological and psychosocial interventions with adult refugees | null |
CRD42023464895 | What medicines have been tried to augment the effects of SSRIs in subjects diagnosed with OCD less than 18 years of age, who have been resistant or refractory to SSRI treatment?
What is the pooled effect size of pharmacological augmentation strategies and of individual medications used for augmentation as measured by s... | Obsessive compulsive disorder (OCD) is a known mental health disorder characterized by obsessions, that are repetetive, and intrusive thoughts, images or ideas that are considered irrational or excessive by an individual, and by compulsions, that are repetetive physical or mental acts to relieve anxiety related to obse... | null |
CRD42025638194 | Our study aims to evaluate the effectiveness and safety of treatments for constipation during pregnancy through a network meta-analysis. Specifically, you plan to compare the efficacy of various pharmacological and non-pharmacological interventions in alleviating constipation symptoms in pregnant women, as well as thei... | Constipation is a common gastrointestinal issue during pregnancy, affecting maternal quality of life and potentially leading to complications such as hemorrhoids. Chronic constipation increases intra-abdominal pressure, placing excessive stress on the pelvic floor muscles. This elevates the risk of postpartum pelvic fl... | null |
CRD42023447589 | the long-term evolution of cognitive impairments following a First Episode of Psychosis (FEP) remains contentious. Previous reviews have focused on the first 5 years after the onset of psychosis, and reported that cognition was stable or even improved during that time. However, more recent studies looking at longer fol... | We are investigating changes in cognition, longitudinally, after the FEP. Here, changes in cognition refers to changes in domain-specific performance of the MATRICS cognitive domains, such as attention, processing speed, verbal and visual learning, social cognition, problem-solving, reasoning, and working memory. | null |
CRD42024606008 | In existing genetic case-control studies of PTSD, which gene polymorphisms have a significant impact on the diagnosis of PTSD under different conditions of diagnostic criteria, age groups, types of trauma, ancestry and whether the control group experienced the same trauma?" | Posttraumatic Stress Disorder; Genetics.
Posttraumatic stress disorder (PTSD) is a clinically observable phenomenon that occurs following significant traumatic events, such as war, natural disasters, or other stressful events. Over the past decade, the literature on genetic variation in the field of PTSD has grown annu... | null |
CRD420250645453 | How does facial symmetry influence perceived attractiveness, and what role do moderating factors such as averageness, distinctiveness, and masculinity/femininity play in this relationship? | This systematic review examines the impact of facial symmetry on perceived attractiveness within the field of facial aesthetics. Symmetry is often linked to genetic quality and developmental stability, but its role in attractiveness remains debated. This review aims to assess the evidence on symmetry’s influence on att... | Exclusion: • Studies using moving or dynamic stimuli (e.g., videos, moving faces). • Studies where symmetry was manipulated along with other facial features (e.g., skin tone, interocular distance) unless symmetry was analyzed separately. • Studies evaluating regional symmetry (e.g., only the chin or eyes) only instead ... |
CRD42023447031 | 1) What is the evidence on the effectiveness of gatekeeper training programs on promoting suicide prevention literacy and gatekeeper behaviours in low- and middle-income countries (LMICs)?2) What are the key characteristics of gatekeeper training programs evaluated in LMICs?3) Is there any evidence that gatekeeper trai... | Suicide Inclusion: All potential "gatekeepers", that is, anyone who may have contact with individuals at risk of suicide, including but not limited to doctors, nurses, police, counsellors, teachers, caregivers, etc. Community-centred approach Inclusion: Educational interventions or programs that provide skills training... | Exclusion: (a) programs that provide no skills training in helping other people in distress; (b) treatment, therapeutic, or psychoeducational programs aimed at preventing or reducing psychological symptoms (e.g., stress management programs, psychoeducational or CBT-based programs to prevent or reduce symptoms of depres... |
CRD42023408373 | 1. How strong is the existing published evidence for the effects of perinatal depression interventions on depressive symptoms and disorders?
2. To what extent are the effects of perinatal depression interventions durable?
3. If beneficial effects are observed across studies, to what degree is there risk of bias in thes... | Depressive symptoms and disorders as measured by instruments whose psychometric properties have been established in prior studies. | null |
CRD420250650682 | What is the effect of compound climate events and disasters on health and well-being for populations and communities globally who are exposed to compound hazards compared to populations who are exposed to singular hazards or not exposed at all? | Well-being; Healthcare services; Morbidity; All Cause Mortality; Health Care Utilization Measures of health such as mental health, disease prevalence, mortality, and healthcare access impacted by direct compound climate exposure or indirectly through food insecurity and displacement. All populations globally in high-, ... | null |
CRD420250607165 | The facilitators and barriers of the emotional literacy support assistant intervention | Emotional intelligence; Emotional Support Education; Emotional Support Wellbeing intervention - Emotional Literacy Support Assistants (ELSA) - school based intervention. Inclusion: published research of the emotional literacy support assistant intervention, intervention supporting children ages 5 - 18 years old in the ... | Exclusion: adults (over 18), research focussed on any other intervention. |
CRD42024505158 | What are the most commonly utilized Patient-Reported Outcome Measures (PROMs) for assessing Health-Related Quality of Life (HRQoL) in children with short stature?
How do these measures contribute to our understanding of the psychosocial and emotional well-being of this population? | Achondroplasia, Growth Hormone Deficiency, and Small-for-Gestational-Age | null |
CRD420250581208 | How does being diagnosed or living with Pulmonary Hypertension affect how a person sees themselves (self-image/self-concept) | Pulmonary Hypertension; Poor Self-image Pulmonary hypertension (PH) is a condition characterised by high blood pressure in the arteries of the lungs occurring when the blood vessels in the lungs constrict or become blocked, restricting blood to flow through the lungs. This forces the right side of the heart to work har... | Exclusion: Does not include PH or PAH as a listed condition Self-Image/self-concept outcomes focus only on carers. Perinatal and Infant Populations Exclusion: Studies that do not explicitly report PH in their sample. No impact to the self-concept/self-image is identified. Papers that only report medical outcomes. Outco... |
CRD420251004025 | What are the reported sensory outcomes (e.g., monofilament threshold, vibration detection, temperature perception) following NAC reinnervation in gender-affirming mastectomy? | This review will include studies involving individuals undergoing gender-affirming mastectomy (also referred to as transmasculine chest reconstruction or top surgery) who receive targeted nipple-areola complex (NAC) reinnervation. Eligible populations include: Transgender and gender-diverse individuals assigned female ... | Cisgender patients undergoing NAC neurotization for oncologic mastectomy unless gender-affirming cases are analyzed separately. Patients under 16 years old. Studies without documented NAC reinnervation techniques. Case reports, reviews, and non-human studies. |
CRD420250642508 | What interventions have been developed, and how effective are they in supporting the MH and Wellbeing of Service Personnel | Military mental health prevention interventions Serving military personnel; prevention of mental ill health; english language; Peer reviewed, empirical research; Published between Jan 2006 and Jan 2023. Papers were eligible for inclusion if they reported an intervention designed and delivered with military personnel, a... | non-military environments, interventions for people with diagnoses of mental ill health (that is, not prevention), non-western militaries, veterans, and non-empirical research. |
CRD42023396368 | What are eating disorder treatment outcomes and experiences for autistic individuals with an eating disorder? | Autistic individuals with current or lifetime history of an eating disorder (ED), including but not limited to, anorexia nervosa (AN), binge eating disorder (BED), bulimia nervosa (BN), avoidant restrictive food intake disorder (ARFID) or eating disorder not otherwise specified (EDNOS). | null |
CRD420251017388 | to investigate in the literature the differences in clinical, psychiatric, sociodemographic, cognitive and prognostic variables between obese bipolar patients when compared to non-obese ones | Studies that met the following criteria were included in this systematic review: 1) Articles published up to March 10, 2025. 2) Being an analytical study (ecological; cross-sectional; case-control; cohort) in which the sample should be at least 30 patients. Longitudinal and cross-sectional trials were selected, in addi... | Studies that did not meet these criteria, as well as duplicates (e.g., dissertations and theses published in other forms, such as scientific articles, books or book chapters), were excluded from the scope of the review. Literature review articles, systematic reviews, in vitro or animal studies, studies that referred to... |
CRD42024513550 | How do specific components of the fungal cell wall modulate the immune system in humans? | Fungal cell wall components, such as β-glucans and chitin, are notable for their ability to interact with the immune system. β-Glucans are fungi, yeasts, algae and many other organisms. They are recognised by the immune system and can trigger a range of immune responses. Chitin, is also found in the cell walls of fungi... | null |
CRD42022344954 | In children with autism, is equine assisted therapy an effective intervention for improving stress resilience and
executive function? | Autism Spectrum Disorder is a neurodevelopmental disorder in which the core symptom domains are constituted by
deficits in social communication as well as restricted, repetitive patterns of behaviour and interest (DSM 5th edition)
Further symptoms related to these challenges include intellectual and language delays as ... | null |
CRD42021281478 | Primary: Does the perception of body image differ between Latino adults (≥ age 18) and their white peers in the United States? What factors are associated with body image for Latino adults?
Secondary: Does the perception of body image differ between LGBTQ+ Latino adults (≥ age 18) and their cis-gender heterosexual Lati... | Body image, as dictated by the National Eating Disorder Association, encompasses an individual’s thoughts about their own appearance, how they feel about their body, and how they sense and control their body in movement.
Thoughts about appearance can include memories, assumptions, and generalizations about one’s body. ... | null |
CRD420250636525 | What is the trustworthiness and reporting quality of randomized trials on pharmacological and psychological interventions for preventing chronic pain after orthopedic and musculoskeletal surgeries?How do these aspects, assessed using the TRACT and CONSORT checklists, relate to bibliographic characteristics such as jour... | Chronic Postoperative Pain; Psychiatric Pharmacologic Management; Therapeutic Psychology Chronic pain following orthopedic and musculoskeletal surgeries is a persistent condition that significantly affects patients' quality of life, functional abilities, and mental health. Despite advances in surgical techniques and pe... | The exclusion criteria for this review include trials involving pediatric patients, studies assessing acute pain or pain within three months post-surgery, studies without relevant outcome data, dose-finding studies, and trials combining treatments with non-uniform co-interventions such as physical therapy. We will excl... |
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